Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Endo-peptidases, a group of enzymes that cleave peptide bonds within proteins, are included in some therapeutic protocols for injury management, primarily for their potential anti-inflammatory and fibrinolytic properties. Examples include bromelain (from pineapple) and serratiopeptidase (from bacteria). Scientific rationale for their use centers on their ability to reduce inflammation, edema, and possibly pain associated with soft tissue injuries by breaking down inflammatory mediators and facilitating the resorption of protein debris from damaged tissues.

A number of small-scale clinical trials and animal studies suggest that certain endo-peptidases can modestly accelerate recovery from injuries such as sprains, strains, or post-surgical trauma, mainly by reducing swelling and improving microcirculation. For instance, bromelain has demonstrated some efficacy in reducing pain and swelling after surgery or blunt trauma. Serratiopeptidase has been studied for its potential to decrease swelling and pain, although results are inconsistent and often limited by methodological weaknesses.

However, the overall quality of evidence is low to moderate, with most studies being small, heterogeneous, and sometimes lacking rigorous controls. Major medical guidelines do not currently endorse endo-peptidase supplementation as a standard treatment for injuries. While the mechanistic basis is plausible and preliminary data are promising, more robust randomized controlled trials are needed to establish efficacy and optimal dosing.

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