NatureWise Organic Turmeric Curcumin Guide

Name: Turmeric Curcumin (Formerly CurcuminBP)
Brand: Nature's Sunshine
SKU: 238
Price: 44.95 USD
Availability: InStock
Rating: 4.9 (35 reviews)

Discover how NatureWise organic Turmeric Curcumin supports joints, healthy inflammation response, and antioxidant defense. Learn about key ingredients and usage.

Overview

What Is NatureWise Organic Turmeric Curcumin?

Nature's Sunshine Turmeric Curcumin (Formerly CurcuminBP) is a thoughtfully formulated supplement designed to promote a healthy inflammatory response while supporting joint, skin, brain, and gut health as well as immune system function. Each serving delivers 1,100 mg of Turmeric extract and 1,000 mg of curcuminoids — the potent, antioxidant-rich active compounds found in the rhizomes of the yellow curry spice Turmeric (Curcuma longa L.).

What sets this naturewise organic Turmeric Curcumin formula apart is its emphasis on delivering higher levels of the concentrated Turmeric extract alongside the whole Turmeric root. One serving is equivalent to 32,000 mg of whole root Turmeric, and the formula has been clinically studied for superior absorption and effectiveness.

Curcumin has been safely used for centuries in Indian Ayurvedic medicine and has attracted extensive modern research for its role in supporting the body's natural inflammatory response and antioxidant defense systems. To further enhance the formula, Black pepper extract is included to improve the bioavailability and absorption of Curcumin — addressing one of the most significant challenges in Curcumin supplementation.

How It Works

Why Turmeric Curcumin Matters for Inflammation and Joint Health

Chronic inflammation sits at the root of many common health concerns, from stiff, uncomfortable joints to diminished immune resilience. Curcumin, the principal bioactive polyphenol in Turmeric, has been extensively investigated for its capacity to modulate multiple signaling pathways involved in regulating inflammatory responses.

Research suggests that Curcumin exerts its core anti-inflammatory effects mainly by inhibiting the activation of the NF-κB signaling pathway and suppressing the activity of COX-2 and LOX enzymes — which are responsible for producing inflammatory mediators including prostaglandins and leukotrienes. It also acts by reducing the production of inflammatory cytokines such as TNF-α and IL-1β, while scavenging reactive oxygen species (ROS) to help protect cartilage from degradation.

On the antioxidant front, studies suggest Curcumin activates the Keap1-Nrf2/ARE transcriptional pathway, which upregulates endogenous cytoprotective enzymes. Multiple human randomized controlled trials and meta-analyses have shown that Curcumin supplementation measurably raises total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase, and glutathione, while lowering the lipid-peroxidation marker malondialdehyde (MDA).

This formula also includes Black pepper extract containing piperine, which research has shown can increase Curcumin bioavailability by approximately 2,000% in humans. Because Curcumin's greatest challenge is its naturally poor oral absorption, this pairing is especially meaningful for getting the most from each serving.

What's inside

Key Ingredients

Tumeric Extract — 1,100 mg

Turmeric (Curcuma longa L.) is a rhizomatous herbaceous perennial plant from the ginger family, native to tropical South Asia, with a nearly 6,000-year history of use in Ayurvedic medicine and traditional Chinese medicine. The Turmeric extract in this formula is standardized for curcuminoid content — curcuminoids being the primary active compounds responsible for Turmeric's vibrant color and its researched health properties. Research suggests that Turmeric extract supports a healthy inflammatory response by inhibiting the NF-κB signaling pathway and suppressing COX-2 and LOX enzyme activity, effectively curtailing the production of inflammatory mediators. Multiple meta-analyses and systematic reviews support a statistically significant benefit of Turmeric extract for knee osteoarthritis pain and function, with some evidence of comparable efficacy to NSAIDs. Studies also suggest it supports cartilage health by protecting against degradation driven by inflammatory cytokines like IL-1β and TNF-α. A landmark comparative RCT (n=367 knee OA patients) found Turmeric extract equivalent to ibuprofen for knee pain relief. A 2025 network meta-analysis of 39 RCTs confirmed Curcumin/Turmeric ranked among the supplements with significant benefits for joint function. Beyond joint health, research suggests Turmeric extract may support flexibility and mobility, promote antioxidant defense by raising total antioxidant capacity and SOD levels, and has been studied in the context of rheumatoid arthritis, gout, and bursitis — conditions where inflammatory pathways play a central role. It has traditionally been used in Ayurvedic medicine for inflammatory conditions, digestive disorders, and skin health.

Curcuminoids — 1,000 mg

Curcuminoids are the family of phenolic pigments in Turmeric responsible for its yellow color and most of its researched biological activity. The group includes Curcumin (diferuloylmethane, the dominant and most potent constituent), demethoxycurcumin, and bisdemethoxycurcumin. Research suggests curcuminoids support chronic inflammation management by inhibiting NF-κB, COX-2, MAPK, JAK/STAT, and the NLRP3 inflammasome — all key pro-inflammatory pathways. Multiple meta-analyses of randomized controlled trials demonstrate significant reductions in key inflammatory biomarkers including CRP, IL-6, and TNF-α following Curcumin supplementation. For joint health specifically, a meta-analysis of 29 RCTs (2,396 participants across five arthritis types) confirmed significant pain and inflammation reductions, and a 2014 head-to-head RCT found 1,500 mg/day Curcumin equivalent to ibuprofen 1,200 mg/day in knee OA. A 2025 systematic review of 21 studies in knee OA found Curcumin groups had significantly lower CRP and TNF-alpha levels versus placebo. Curcuminoids also support antioxidant defense: clinical evidence shows they significantly reduce malondialdehyde (a lipid peroxidation marker) and raise enzymatic antioxidants including SOD, catalase, and glutathione peroxidase, primarily through activation of the Nrf2-Keap1 signaling axis. Research also suggests curcuminoids may support flexibility and mobility, cartilage health, and have been studied for their potential role in rheumatoid arthritis and bursitis. A key limitation across studies is Curcumin's inherently poor oral bioavailability, which is why this formula pairs curcuminoids with Black pepper extract.

Black pepper Extract

Black pepper (Piper nigrum L.), known as the 'King of Spices,' contains the alkaloid piperine as its major bioactive compound. In this formula, Black pepper extract serves a critical role: enhancing the bioavailability and absorption of Curcumin. Research has shown that in humans, Curcumin bioavailability was increased by approximately 2,000% when co-administered with piperine. The mechanism is well-characterized — piperine inhibits UDP-glucuronosyltransferase (UGT) enzymes that would otherwise rapidly conjugate and eliminate Curcumin, and it also inhibits P-glycoprotein and CYP3A4, reducing drug efflux and metabolism. Beyond its bioenhancing role, piperine has its own researched properties. Studies suggest it inhibits COX-2 gene expression and PGE2 production, and in vitro research using human rheumatoid arthritis synoviocytes showed piperine inhibited IL-6, MMP13, COX-2, and PGE2 in a dose-dependent manner. Human RCTs using Curcumin-piperine combinations have documented improvements in oxidative stress markers including superoxide dismutase, total antioxidant capacity, and malondialdehyde, as well as significant reductions in CRP, hs-CRP, and IL-6 in metabolic syndrome populations. Black pepper is listed by the FDA as generally recognized as safe (GRAS) and has been used traditionally in Ayurvedic medicine for thousands of years, where it forms part of the classical herbal preparation trikatu and is documented in texts like the Charaka Samhita for digestive and respiratory support.

Dicalcium Phosphate

Dicalcium phosphate is a Calcium-based compound used in this formula as a processing aid. Calcium is the most abundant mineral in the human body, with more than 99% stored in bones and teeth as hydroxyapatite. It plays essential roles in muscle contraction, neuronal transmission, hormone secretion, and cell signaling. Calcium participates in the mineralization of calcified tissues and is tightly regulated by the parathyroid-vitamin D-calcitonin endocrine axis. In this supplement, dicalcium phosphate contributes a small amount of Calcium as part of the capsule formulation rather than serving as a primary therapeutic ingredient.

Turmeric Curcumin (Formerly CurcuminBP)

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Turmeric Curcumin (Formerly CurcuminBP)

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Ideal For

Who Is This Turmeric Curcumin Formula For?

This naturewise organic Turmeric Curcumin formula is designed for adults looking for natural support for their body's inflammatory response. It may be particularly well-suited for those who experience occasional joint stiffness or discomfort, or anyone seeking to support overall joint, skin, brain, and gut health.

Active individuals who want to help maintain flexibility and mobility, as well as those interested in bolstering their antioxidant defense, may find this formula relevant. Research suggests Curcumin supplementation may also support immune system function and promote healthy microbiome balance.

This product is non-GMO and comes in vegetable capsules (VegCaps), making it suitable for those who prefer plant-based supplement options. If you're unsure whether this formula is right for your individual needs, our naturopath is available for a free consultation — we're always happy to help you find the best approach for your wellness goals.

Usage

How to Take Turmeric Curcumin

Take 2 VegCaps daily. Each bottle contains 60 caps, providing a 30-day supply at the recommended serving size.

Because this formula includes Black pepper extract to support Curcumin absorption, no additional steps are needed to optimize bioavailability — the formulation is designed to work together as a complete serving.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

Why is Black pepper extract included in this Turmeric Curcumin formula?

Curcumin naturally has poor oral bioavailability due to low water solubility, poor intestinal permeability, and rapid metabolism. Black pepper extract contains piperine, which research has shown can increase Curcumin bioavailability by approximately 2,000% in humans. Piperine works by inhibiting enzymes (UGT) and transporters (P-glycoprotein) that would otherwise quickly break down and eliminate Curcumin from the body. Black pepper extract may also aid with some occasional digestive discomfort and has its own antioxidant properties.

What are curcuminoids and why do they matter?

Curcuminoids are a family of polyphenolic compounds found in the Turmeric rhizome, responsible for its characteristic yellow color and most of its researched biological activity. The three main curcuminoids are Curcumin (the most potent and abundant), demethoxycurcumin, and bisdemethoxycurcumin. This formula provides 1,000 mg of curcuminoids per serving. Research suggests curcuminoids support a healthy inflammatory response by modulating key pathways including NF-κB, COX-2, and MAPK, and they may help support joint comfort, antioxidant defense, and immune function.

How does this formula compare to whole root Turmeric?

While whole Turmeric root powder typically contains only about 2–5% curcuminoids by weight, this formula uses a concentrated Turmeric extract to deliver significantly higher levels of these active compounds. Nature's Sunshine states that one serving is equivalent to 32,000 mg of whole root Turmeric, providing both Turmeric root and higher levels of the antioxidant-rich Turmeric extract in each dose.

What joint conditions has Turmeric Curcumin been studied for?

Turmeric and Curcumin have been studied most extensively for knee osteoarthritis, with multiple systematic reviews and meta-analyses supporting statistically significant benefits for pain and function compared to placebo. A 2022 meta-analysis of 29 RCTs covering 2,396 participants examined five types of arthritis including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, and gout. Some evidence suggests comparable efficacy to NSAIDs, though evidence quality is generally rated as low to very low, and more research is warranted.

Is this product non-GMO?

Yes, this Turmeric Curcumin formula is non-GMO. It comes in vegetable capsules (VegCaps) with a recommended serving size of 2 capsules daily.

Can I talk to someone about whether Turmeric Curcumin is right for me?

Absolutely. We offer free naturopathic consultations — our naturopath can help you understand how this supplement fits into your individual wellness plan and answer any questions about ingredients, usage, or how Turmeric Curcumin may support your specific health goals.

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