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Nature’s Sunshine Combination CBG Extract | Immune

Discover Nature's Sunshine Combination CBG Extract, a spagyric liquid formula with six herbs to nourish the immune system and support stress relief.

Overview

What Is Nature's Sunshine Combination CBG Extract?

Nature's Sunshine Combination CBG Extract is a unique liquid herbal formula crafted to nourish the immune system and support your body's response to stress. Unlike standard capsules or tablets, this 2 fl oz extract offers a convenient alternative for anyone who prefers not to swallow pills.

What makes this formula distinctive is the way it's made. Through a traditional process called the spagyric process, the raw herbs are soaked in a natural solution before the plant fiber is removed and reduced to ash. The liquid and ash are then recombined into the finished CBG extract, along with alcohol to preserve the active ingredients. This time-honored method is designed to capture a broad profile of each herb's constituents.

The result is a concentrated blend of six classic botanical ingredients β€” Black cohosh root, Chickweed aerial parts, Goldenseal root, Passionflower aerial parts, Chinese Licorice root, and Valerian root β€” each contributing its own traditional and researched properties to the formula.

How It Works

A Synergistic Blend for Immune and Stress Support

Nature's Sunshine Combination CBG Extract brings together herbs that have been valued across Native American, European, and Chinese herbal traditions for centuries. The formula is built around three interconnected goals: immune nourishment, viral immune response support, and stress relief.

Several of the herbs in this blend β€” Goldenseal root, Chickweed aerial parts, and Chinese Licorice root β€” have long histories of traditional use for immune challenges. Goldenseal contains the alkaloid berberine, which has demonstrated broad-spectrum antimicrobial activity in laboratory studies. Chickweed has been used traditionally as a lymphatic alterative and has shown immunomodulatory activity in preclinical research. Chinese Licorice root contains glycyrrhizin, which has documented antiviral activity against multiple viruses in research settings.

The calming side of the formula relies on Passionflower and Valerian root, two of the most well-studied botanicals for nervous tension. Research suggests Passionflower may support relaxation through GABAergic modulation, while Valerian root's valerenic acid has been shown to act as a positive allosteric modulator of GABA-A receptors. Black cohosh root adds further nervous system support through its documented activity on serotonin, dopamine, and other central pathways.

If you have questions about how these herbs might fit into your personal wellness routine, our naturopath is available for a free consultation β€” just reach out.

What's inside

Key ingredients

Black cohosh Root β€” 940 mg
Black cohosh (Actaea racemosa) is a perennial plant native to eastern North America with a long history of use by Native American tribes, including the Cherokee, Iroquois, and Delaware, for a wide range of conditions. The root and rhizome contain triterpene glycosides (such as actein and 23-epi-26-deoxyactein), phenolic acids, and the serotonin derivative Nω-methylserotonin. Black cohosh exerts documented activity on multiple central nervous system pathways, including serotonin, dopamine, and μ-opioid receptor systems, supported by in vitro and PET neuroimaging studies. Clinical evidence from multiple randomized controlled trials suggests it may help reduce anxiety and mood symptoms associated with menopause, and it is listed among promising herbs for anxiety in systematic reviews of herbal medicine. A randomized, double-blind, placebo-controlled trial using polysomnography found significant improvements in sleep efficiency and reduced wake-after-sleep-onset duration in postmenopausal women.
Chickweed Aerial Parts β€” 940 mg
Chickweed (Stellaria media) is a cool-season herb from the Caryophyllaceae family, originally native to Eurasia and now one of the most widespread plants on the planet. Its aerial parts contain over 80 identified secondary metabolites, including flavonoids (apigenin, rutin, quercetin), phenolic acids (ferulic, chlorogenic, caffeic acid), saponins, vitamins (A, B, C, D), and minerals (calcium, iron, potassium, zinc). Traditionally, Chickweed has been classified as a cooling refrigerant herb and used in hot infusion form to help reduce fevers across European and Asian herbal traditions. It is consistently described in Western herbalism as a lymphatic alterative, traditionally used to support the cleansing function of the lymphatic system, help move lymphatic fluid, and reduce swollen glands. Preclinical studies have demonstrated immunomodulatory activity, with Chickweed extracts reducing pro-inflammatory cytokines (IL-6, COX-2) in human immune cells (PBMCs) and showing potential antiviral activity in laboratory settings.
Goldenseal Root β€” 940 mg
Goldenseal (Hydrastis canadensis) is a perennial herb native to North American forests, prized by Native American tribes β€” including the Cherokee, Iroquois, Micmac, and Potawatomi β€” for its medicinal root. Its primary active alkaloids include berberine (approximately 2.5%), hydrastine (1.5–4%), and canadine (0.5%). Goldenseal has a well-documented traditional history for cold and flu, used in combination with echinacea in many commercial preparations, though clinical studies have not yet proven efficacy for colds specifically. It has been traditionally employed by Indigenous peoples and Western herbalists for upper respiratory health, sinus infections, tonsillitis, swollen lymph nodes, and viral conditions. Berberine has demonstrated antimicrobial activity against a wide range of pathogens in laboratory studies, and research supports its antiviral activity against multiple viruses. An animal study showed Goldenseal may support immune function by increasing production of antigen-specific immunoglobulins. Goldenseal also has traditional use as an antiperiodic (fever-reducing) agent, documented in both Eclectic and Native American medicine.
Passionflower Aerial Parts β€” 940 mg
Passionflower (Passiflora incarnata) is a perennial vine native to the Americas, traditionally used as a sedative, antispasmodic, and nervine by Indigenous peoples across North, Central, and South America. Its key active constituents include the flavonoids chrysin, apigenin, vitexin, and isovitexin, along with trace Ξ²-carboline alkaloids. Research suggests Passionflower supports calm and relaxation primarily through GABAergic modulation β€” whole extract has been shown to elicit direct GABA-A currents in hippocampal neurons in vitro, and its flavonoids act as partial agonists at benzodiazepine receptor sites. A landmark double-blind RCT found Passionflower comparable in efficacy to oxazepam (a benzodiazepine) for generalized anxiety disorder, with fewer adverse effects on job performance. Additional clinical studies suggest it may support stress relief and emotional resilience, with multiple systematic reviews confirming anxiolytic properties. Controlled clinical research has also demonstrated improvements in both subjective and objective sleep parameters, and ESCOP endorses Passionflower for nervous restlessness and mild sleep disturbances.
Chinese Licorice root β€” 940 mg
Licorice root (Glycyrrhiza species, including G. uralensis β€” Chinese licorice) has been used in traditional medicine for over 4,000 years, appearing in approximately 60% of traditional Chinese medicine prescriptions. Its primary active compound, glycyrrhizin, inhibits the enzyme 11Ξ²-hydroxysteroid dehydrogenase type 2 (11Ξ²-HSD2), thereby extending cortisol availability in tissues β€” a mechanism directly relevant to adrenal support and stress management. Glycyrrhizin and related compounds have documented antiviral activity against multiple viruses, including SARS-CoV, influenza, HSV, HCV, and HBV in research settings. The German Commission E approves licorice for catarrhal conditions of the upper respiratory tract, and the EMA recommends it as an expectorant for cough associated with the common cold. Research also suggests licorice modulates immune function through anti-inflammatory, antihistaminic, and immunostimulating activities. Traditionally, it has been used for sore throat, cough, bronchitis, and respiratory infections across TCM, Ayurvedic, and European herbal systems.
Valerian root β€” 940 mg
Valerian (Valeriana officinalis) is a perennial herb whose root has been used since the time of Hippocrates and Galen as a remedy for insomnia, anxiety, and nervous tension. Its primary active constituent, valerenic acid, acts as a positive allosteric modulator of GABA-A receptors, enhancing inhibitory neurotransmission. Additional mechanisms include inhibition of GABA-transaminase (reducing GABA breakdown) and modulation of serotonin (5-HT5a) receptors involved in sleep-wake cycles. The German Commission E and ESCOP approve valerian for nervous unrest and sleep disorders. A systematic review and meta-analysis of 60 studies (n=6,894) evaluated its effectiveness for sleep problems and anxiety, with some clinical trials demonstrating improvements in subjective sleep quality at daily doses of 300–600 mg. Research suggests valerian may also support emotional resilience and calm, though clinical evidence for anxiety specifically remains mixed.
Combination CBG Extract
Combination CBG Extract
β˜…β˜…β˜…β˜…β˜… 5.0 (8 reviews)
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Combination CBG Extract
Combination CBG Extract
$47.65
Who Benefits

Who Is Nature's Sunshine Combination CBG Extract For?

This formula may be a good fit for adults who want to nourish their immune system while also addressing the tension and restlessness that can accompany seasonal immune challenges or stressful periods. The combination of immune-supportive and calming herbs makes it especially relevant during times when your body is working harder to maintain balance.

Because it comes in liquid extract form, Nature's Sunshine Combination CBG Extract is also a practical choice for people who have difficulty swallowing tablets or capsules. The liquid format allows for easy dosing with just a half teaspoon mixed into water.

As always, if you're unsure whether this formula aligns with your individual health needs β€” especially if you're taking medications or have specific health concerns β€” we encourage you to take advantage of a free consultation with our naturopath.

Usage Guide

How to Take Combination CBG Extract

Take 1/2 teaspoon (2.5 mL) three times daily with water.

The liquid format makes it simple to incorporate into your morning, afternoon, and evening routines. Because the extract contains alcohol as a preservative for the active ingredients, mixing it into a small glass of water can help make the taste more palatable.

About the author

Written by Greg Howlett

GH

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What does CBG stand for in Nature's Sunshine Combination CBG Extract?

CBG refers to the Combination formula name used by Nature's Sunshine for this particular herbal blend. It is not related to cannabigerol (a cannabinoid). This product contains a spagyric extract of six traditional herbs β€” Black cohosh root, Chickweed aerial parts, Goldenseal root, Passionflower aerial parts, Chinese Licorice root, and Valerian root.

What is the spagyric process used to make this extract?

In the spagyric process, the raw herbs are soaked in a natural solution before the plant fiber is removed and reduced to ash. The liquid and ash are later recombined into the finished CBG extract, along with alcohol which preserves the active ingredients. This traditional method is designed to capture a broad range of each herb's constituents.

Can I take this extract if I have trouble swallowing pills?

Absolutely. One of the highlights of Combination CBG Extract is that it provides an alternative to swallowing tablets. You simply take 1/2 teaspoon (2.5 mL) mixed with water three times daily.

What are the main uses of Nature's Sunshine Combination CBG Extract?

This formula is designed to nourish the immune system, support a healthy viral immune response, and promote relief from stress. It combines herbs traditionally used for immune health β€” such as Goldenseal, Chickweed, and Chinese Licorice root β€” with calming botanicals like Passionflower, Valerian root, and Black cohosh.

Does this product contain Goldenseal, and is Goldenseal sustainably sourced?

Yes, Goldenseal root is one of the six herbs in this formula. Goldenseal (Hydrastis canadensis) is listed as vulnerable by the IUCN and is included in CITES Appendix II due to concerns about overharvesting. Nature's Sunshine includes Goldenseal as a key ingredient in this blend for its traditional immune-supportive properties.

Should I talk to a healthcare professional before taking this extract?

It's always a good idea to consult a qualified healthcare professional before starting any new supplement, especially if you are pregnant, nursing, taking prescription medications, or have existing health conditions. Several herbs in this formula β€” particularly Goldenseal and Licorice root β€” have documented interactions with certain medications. Our naturopath is available for a free consultation if you'd like personalized guidance.

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