Nature Made Calcium, Magnesium, Zinc Tablets Guide

Name: Calcium-Magnesium (SynerPro)
Brand: Nature's Sunshine
SKU: 3244
Price: 18.60 USD
Availability: InStock
Rating: 4.5 (35 reviews)

An in-depth guide to nature made Calcium, Magnesium, Zinc tablets — what they contain, how they support bone density, muscles, and the nervous system, and how to take them.

Overview

What Are Nature Made Calcium, Magnesium, Zinc Tablets?

Nature made Calcium, Magnesium, Zinc tablets deliver a carefully balanced blend of minerals, vitamins, and botanical concentrates designed to support bone density, muscle function, and nervous system health. Calcium Magnesium SynerPro from Nature's Sunshine pairs two essential minerals — Calcium and Magnesium — that research shows work best when taken together, then rounds out the formula with Vitamin D3, Zinc, Copper, Boron, Phosphorus, and a proprietary SynerPro botanical base.

Calcium Magnesium SynerPro assists the body by strengthening the teeth, bones, skin, and tendons. It also encourages proper circulation and may help balance pH levels. Because heavily processed modern diets tend to strip Magnesium from the foods that once supplied it, supplementation has become necessary for many people — and combining these minerals in a single tablet makes daily support simpler.

Each bottle contains 150 tablets, providing a convenient multi-week supply when taken at the recommended serving size. If you have questions about whether these nature made Calcium, Magnesium, Zinc tablets are a good fit for your routine, our naturopath is available for a free consultation.

How It Works

Why Calcium and Magnesium Work Better Together

Calcium is widely recognized for its importance in bone health, but it also supports the muscular system, the nervous system, and the circulatory system. More than 99% of the Calcium in the body is stored in bone as hydroxyapatite, providing skeletal strength as well as a reservoir that can be released into the bloodstream when needed.

Magnesium stimulates enzyme activity in the body and, when used alongside Calcium, also supports muscular and nervous system health. It is a cofactor in more than 300 enzyme systems, helping regulate everything from protein synthesis and blood glucose control to blood pressure and nerve function. Research suggests that higher Magnesium intake is associated with greater bone mineral density in women, and a systematic review found that supplementation may help attenuate bone loss.

Because the body depends on vitamin D to absorb Calcium efficiently, this formula includes Vitamin D3 — the form studies suggest is more potent than D2 at raising serum 25(OH)D levels. Zinc, Copper, Boron, and Phosphorus round out the mineral profile. Together with a SynerPro base of Broccoli flower, Carrot root, red Beet root, Rosemary leaf, Tomato fruit, Cabbage leaf, Grapefruit bioflavonoid, Orange bioflavonoid, Hesperidin, and Turmeric root, these nutrients come from natural sources to provide broad-spectrum structural support.

What's inside

Key ingredients

Vitamin D3 — 2.5 mcg

Vitamin D3 (cholecalciferol) is a fat-soluble secosteroid that the body converts into its active form, calcitriol, through sequential hydroxylation in the liver and kidneys. Research shows that Vitamin D3 combined with Calcium reduces bone loss, particularly at the hip and spine, and it is endorsed by the WHO, NIH, and major osteoporosis guidelines as the preferred supplemental form for bone health. It supports musculoskeletal function by enhancing intestinal Calcium and Phosphorus absorption critical for bone mineralization. Studies also suggest that supplementation in deficient individuals improves muscle strength and reduces fall risk, while its role in chondrocyte function makes it relevant to joint mobility.

Calcium — 400 mg

Calcium is the most abundant mineral in the human body and the primary structural component of bone. Meta-analyses of randomized controlled trials demonstrate that Calcium supplementation significantly improves bone mineral density (BMD), especially in people under 35 building peak bone mass. Combined with vitamin D, it may attenuate bone loss in older adults. Calcium is also essential for muscle contraction and relaxation — low intake is associated with muscle spasms, cramps, and weakness, and correction of hypocalcemia resolves these neuromuscular symptoms. NIH Consensus guidelines recommend adequate Calcium for postmenopausal women and the elderly to help slow bone loss and improve density across life stages.

Phosphorus — 250 mg

Phosphorus is the second most abundant mineral in bone, forming hydroxyapatite with Calcium as the primary mineral matrix of skeletal tissue. It is also a building block of DNA, RNA, and ATP — the body's major energy source — and regulates normal nerve and muscle function. Deficiency causes rickets in children and osteomalacia in adults. Phospholipids containing Phosphorus are essential structural components of neuronal cell membranes and are required for synaptic neurotransmission. Adequate Phosphorus intake alongside Calcium is recognized as vital for bone health and skeletal development by major health bodies including the NIH.

Magnesium — 200 mg

Magnesium is a cofactor in more than 300 enzyme systems that regulate biochemical reactions throughout the body. It is essential for bone formation and influences the activities of osteoblasts and osteoclasts, while also affecting concentrations of both parathyroid hormone and the active form of vitamin D — major regulators of bone homeostasis. Observational data from large cohort studies found that higher Magnesium intake is associated with 2–3% greater bone density in women. Magnesium also acts as a natural NMDA receptor antagonist, modulating synaptic transmission and neuronal excitability. Deficiency is associated with muscle cramps, fatigue, weakness, and cardiovascular abnormalities, and a 2024 systematic review found supplementation reduced muscle soreness and supported recovery in physically active individuals.

Zinc — 7.5 mg

Zinc is an essential trace element required for the activity of more than 300 enzymes. It serves as a cofactor for alkaline phosphatase and enzymes critical to bone matrix synthesis and remodeling — clinical evidence links Zinc deficiency with reduced BMD, and supplementation studies suggest Zinc supports bone formation markers. Zinc is also required for proper nervous system function; it modulates NMDA receptor activity, synaptic plasticity, and neurogenesis. Deficiency impairs muscle protein synthesis and reduces testosterone levels, which can affect muscle anabolism and physical performance.

Copper — 1 mg

Copper is an essential cofactor for lysyl oxidase, the enzyme responsible for crosslinking collagen and elastin fibers in the bone matrix. Copper deficiency causes bone abnormalities including osteoporosis-like lesions and impaired collagen crosslinking. The NIH and National Academy of Sciences recognize Copper as a micronutrient relevant to bone metabolism, and it is consistently included in evidence-based bone supplementation protocols. Copper is also essential for myelination of the brain and spinal cord and for neurotransmitter synthesis via dopamine β-hydroxylase; deficiency is documented to cause myelopathy and peripheral neuropathy in clinical case series.

Boron — 0.5 mg

Boron is a trace mineral the World Health Organization considers "probably essential" for humans. It modulates vitamin D hydroxylation, may delay estrogen and vitamin D degradation, and influences Calcium and Magnesium metabolism relevant to bone. In a seminal metabolic ward study, 3 mg/day of Boron in postmenopausal women reduced urinary Calcium excretion by 44% and significantly elevated serum 17β-estradiol concentrations. A 2024 pilot study found improved bone mineral density with increased Boron intake in postmenopausal women. The brain is also a primary target organ for Boron — human EEG studies confirm it modulates brain electrical activity, and cognitive performance is impaired under Boron deprivation.

Broccoli flower — 100 mg

Broccoli flower (Brassica oleracea var. italica) is part of the SynerPro botanical base. It is rich in bioactive glucosinolates, particularly glucoraphanin, which can be converted into sulforaphane — a compound studied for its activation of the Nrf2 pathway, a master regulator of cellular antioxidant defenses. Preclinical evidence suggests sulforaphane inhibits osteoclast activity (bone resorption) and reduces oxidative stress in bone cells. Broccoli is also a dietary source of vitamin K and Calcium, nutrients essential for bone mineralization.

Carrot root — 100 mg

Carrot root (Daucus carota) contributes beta-carotene, the most important provitamin A compound in the human diet. Beta-carotene serves as both a potent antioxidant capable of quenching singlet oxygen and a safe, regulated precursor to vitamin A. Carrots also supply polyacetylenes such as falcarinol, which have demonstrated anti-inflammatory activity in human blood samples, and additional carotenoids including lutein and zeaxanthin.

red Beet root — 100 mg

Red Beet root (Beta vulgaris) is a concentrated source of betalain pigments and inorganic nitrate. Beetroot nitrate-derived nitric oxide increases cerebral blood flow, particularly to the frontal cortex, and some randomized controlled trials show acute improvements in cognitive performance and executive function. Betalains exhibit potent antioxidant and anti-inflammatory activity, scavenging free radicals and helping prevent DNA damage in in vitro and in vivo studies.

Rosemary leaf — 100 mg

Rosemary (Rosmarinus officinalis) has been used in European traditional medicine since antiquity for nervous system stimulation, cognitive enhancement, and headache relief. Its primary bioactive diterpenes — carnosic acid and carnosol — are responsible for approximately 90% of its antioxidant properties and have documented anti-inflammatory effects through modulation of NF-κB and Nrf2 signaling pathways. Human studies show Rosemary supports memory, alertness, and cognitive speed, and EEG data confirm altered brain activity patterns consistent with improved performance.

Tomato fruit — 100 mg

Tomato fruit (Solanum lycopersicum) provides lycopene — one of the most potent antioxidants among dietary carotenoids. In a controlled pilot study of 39 postmenopausal women, those consuming lycopene-rich Tomato sauce daily for three months had no significant bone loss, while control women lost bone (p=0.002). Lycopene activates osteogenic pathways (WNT/β-catenin, ERK1/2) and suppresses bone resorption signaling, offering a plausible mechanism for supporting bone density.

Turmeric root — 100 mg

Turmeric root (Curcuma longa) contains curcumin, a polyphenol with extensively documented anti-inflammatory and antioxidant properties. Multiple systematic reviews and meta-analyses confirm reductions in joint pain and improvements in physical function, particularly in osteoarthritis. Curcumin also exhibits neuroprotective properties including anti-neuroinflammatory and BDNF-upregulating effects. Preclinical studies suggest it promotes osteoblast activity and inhibits osteoclastogenesis, and a small clinical study found a 7% improvement in bone density over six months with a curcumin phytosome supplement.

Cabbage leaf — 100 mg

Cabbage leaf (Brassica oleracea var. capitata) is rich in glucosinolates, flavonoids, and phenolic compounds with documented antioxidant and anti-inflammatory activity. Research supports the traditional use of cabbage in improving inflammation and inflammatory pain. It provides vitamin K1, which is important for bone metabolism, and vitamin C, an essential cofactor for collagen synthesis throughout the musculoskeletal system.

Grapefruit bioflavonoid — 100 mg

Grapefruit bioflavonoid supplies naringin and naringenin — flavanones with anti-inflammatory and antioxidant properties. Research shows these compounds promote the scavenging of reactive oxygen species, inhibit inflammatory cytokine action, and attenuate inflammation via inhibition of NF-κB. One clinical study demonstrated that 400 mg/day of naringin for eight weeks lowered plasma total cholesterol by 14% and LDL by 17% in hypercholesterolemic subjects.

Orange bioflavonoid — 100 mg

Orange bioflavonoid provides Hesperidin and narirutin — the two principal flavanones of Citrus sinensis. Hesperidin has been shown in experimental models to regulate bone metabolism through Wnt/β-catenin signaling and promote osteogenic differentiation. Orange essential oil compounds (limonene, linalool) modulate GABAergic activity and have demonstrated anxiolytic effects in clinical studies, while vitamin C from Orange is an essential cofactor for neurotransmitter synthesis.

Hesperidin — 100 mg

Hesperidin is a citrus flavanone glycoside with multiple documented biological activities. Meta-analyses of randomized controlled trials show it may significantly reduce LDL cholesterol, total cholesterol, triglycerides, and inflammatory markers (TNF-α, CRP). In preclinical studies, Hesperidin promotes osteogenesis by upregulating osteogenic markers and organizing collagen matrix in bone tissue, and a clinical trial (NCT01881204) evaluated Hesperidin combined with Calcium for bone health in postmenopausal women. It also crosses the blood-brain barrier and exerts neuroprotective effects in multiple neurodegenerative disease models.

Calcium-Magnesium (SynerPro)

★★★★★ 4.5 (35 reviews)

✓ Free shipping over $75
✓ 90-day easy returns
✓ Ships within hours

Calcium-Magnesium (SynerPro)

$24.85

Who Benefits

Who May Benefit from These Tablets?

Nature made Calcium, Magnesium, Zinc tablets are formulated for adults seeking comprehensive structural support. They may be especially relevant for:

Adults concerned about bone density — Calcium, Vitamin D3, Magnesium, Zinc, Copper, Boron, and Phosphorus each play documented roles in bone mineralization and bone remodeling. Research suggests that combined Calcium and vitamin D supplementation may reduce bone loss, particularly in older adults and those with confirmed deficiency.
People experiencing occasional muscle cramps — Calcium is essential for muscle contraction and relaxation, and Magnesium deficiency impairs the ability of muscles to fully release after contracting. Ensuring adequate intake of both minerals may help support normal muscle function.
Those wanting nervous system support — Magnesium modulates neuronal excitability as a natural NMDA receptor antagonist, Phosphorus fuels all neural signaling through ATP, and Copper is required for neurotransmitter synthesis. The botanical base adds Rosemary, which has traditionally been used for cognitive enhancement, and Turmeric, which studies suggest has neuroprotective properties.

If you're unsure whether this formula suits your specific needs, our naturopath offers free consultations to help you find the right fit.

Usage

How to Take Calcium Magnesium SynerPro

Take 2 tablets with a meal twice daily. Taking the tablets with food helps support absorption — the concurrent presence of fat in the gut enhances vitamin D absorption, and Calcium carbonate forms are better absorbed in the presence of food.

Each serving of 2 tablets delivers Calcium (400 mg), Magnesium (200 mg), Phosphorus (250 mg), Vitamin D3 (2.5 mcg), Zinc (7.5 mg), Copper (1 mg), Boron (0.5 mg), and a SynerPro botanical base of Broccoli flower, Carrot root, red Beet root, Rosemary leaf, Tomato fruit, Cabbage leaf, Grapefruit bioflavonoid, Orange bioflavonoid, Hesperidin, and Turmeric root (100 mg each).

As with any supplement, consult a healthcare professional before use if you are pregnant, nursing, taking medications, or have a medical condition. If you have questions about how nature made Calcium, Magnesium, Zinc tablets might interact with other supplements you take, our naturopath is happy to help — consultations are always free.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

Why does this formula combine Calcium, Magnesium, and Zinc together?

Calcium and Magnesium work best when used together — Calcium supports bone, muscle, and circulatory health, while Magnesium stimulates enzyme activity and also supports muscular and nervous system function. Zinc is an essential cofactor for alkaline phosphatase and enzymes critical to bone matrix synthesis. Combining them in one tablet provides complementary structural support and simplifies daily supplementation.

Why is Vitamin D3 included in a Calcium-Magnesium supplement?

Vitamin D3 promotes Calcium absorption, which is essential for bone mineralization. Research shows that Vitamin D3 combined with Calcium reduces bone loss, particularly at the hip and spine. Without adequate vitamin D, Calcium absorption from both dietary sources and supplements is significantly diminished, which is why the two nutrients are frequently recommended together.

What is the SynerPro botanical base?

The SynerPro base is Nature's Sunshine's proprietary blend of whole-food concentrates including Broccoli flower, Carrot root, red Beet root, Rosemary leaf, Tomato fruit, Cabbage leaf, Grapefruit bioflavonoid, Orange bioflavonoid, Hesperidin, and Turmeric root. These botanicals supply additional phytonutrients — including carotenoids, bioflavonoids, and antioxidant compounds — from natural sources.

How many tablets are in a bottle and how long does it last?

Each bottle contains 150 tablets. At the recommended serving of 2 tablets twice daily (4 tablets per day), one bottle provides approximately a 37-day supply.

Can I take these tablets if I'm already eating Calcium-rich foods?

Many people do not obtain enough Calcium or Magnesium from diet alone — especially given that heavily processed modern diets tend to remove Magnesium from foods. However, total intake from food and supplements should be considered together. If you're unsure whether your current diet provides enough, our naturopath can help you evaluate your intake during a free consultation.

What role does Boron play in this formula?

Boron is a trace mineral that supports bone health by influencing Calcium, Magnesium, and vitamin D metabolism. In a metabolic ward study, Boron supplementation reduced urinary Calcium excretion by 44% in postmenopausal women. A 2024 pilot study also found a correlation between Boron intake and bone mineral density, highlighting its potential role in supporting skeletal health.

Talk to an expert

Talk to Dr. Shannyn Fowl

Not sure if this is right for you? Book a free, no-pressure consultation for personalized guidance on your health goals.

Book your free consult →

Who we are

About Caring Sunshine

A family-run reseller of premium supplements — free shipping, a 90-day guarantee, and real people who know the products.

Learn more about us →