Magnesium Oxide Supplement | Nervous System & Bone

Magnesium oxide is one of the most concentrated forms of supplemental Magnesium by weight and has been used for generations to help people meet their daily Magnesium needs. Nature's Sunshine Magnesium delivers 250 mg of Magnesium per tablet, combining Magnesium oxide and Magnesium amino acid chelate in a thoughtfully formulated base of Licorice root, Kelp plant, Peppermint leaves, and White willow bark.

Magnesium is the fourth most abundant cation in the human body and a critical cofactor in more than 300 enzyme systems that regulate energy metabolism, neuromuscular function, cardiovascular health, bone integrity, and more. It is required for energy production, oxidative phosphorylation, and glycolysis — making it indispensable for cellular energy generation across virtually all tissues.

This formula is designed to support three interconnected areas of health: nervous system function, bone density, and healthy muscle relaxation. Calcium and Magnesium are nutritional partners and work best when taken together, which is why this formula also includes Calcium alongside Phosphorus for complementary mineral support.

Emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance for Magnesium — a deficiency problem contributing to various health conditions. If you're unsure whether your Magnesium intake is adequate, our naturopath is available for a free consultation to help you evaluate your needs.

Nature's Sunshine Magnesium is used by several hundred enzymes in their daily tasks, helping metabolize various nutrients such as vitamin C, Phosphorus, potassium, and sodium. Magnesium is found in the bones, soft tissues, and blood, where it plays essential roles across multiple body systems.

Nervous System Support: Magnesium modulates neuronal excitability through voltage-gated Calcium antagonism and N-methyl-D-aspartate (NMDA) receptor blockade, helping to regulate normal nerve signaling. Research suggests that deficiency is associated with increased risk of neurological symptoms, and supplementation supports normal nerve function.

Bone Density: Magnesium is involved in bone formation and influences the activities of osteoblasts and osteoclasts. It also affects the concentrations of both parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis. Observational data from large cohort studies found higher Magnesium intake associated with 2–3% greater bone density in women.

Muscle Relaxation: Magnesium is essential for both muscle contraction and relaxation. Research suggests that Magnesium deficiency impairs muscle relaxation, as muscles contract normally but may struggle to fully release when levels are low. A 2024 systematic review found Magnesium supplementation reduced muscle soreness, improved performance and recovery, and exerted a protective effect on muscle damage in physically active individuals.

Energy Production: Mg²⁺ plays a pivotal role in ATP synthesis, the body's primary energy currency. This makes Magnesium oxide supplementation relevant for anyone seeking to support natural energy production at the cellular level.

Proper Elimination: Magnesium supplements are well recognized for promoting healthy bowel regularity by supporting smooth muscle function in the digestive tract.

Because Magnesium is involved in so many fundamental processes, a wide range of people may find this formula supportive. Research suggests that the diets of most people in the United States provide less than the recommended amounts of Magnesium, with men older than 70 and teenage girls being most likely to have low intakes.

Adults concerned about bone health: Magnesium supports bone formation and works alongside Calcium and Phosphorus — all three of which are included in this formula — to promote skeletal integrity. People with higher levels of Magnesium may have higher bone mineral density, which is important in helping reduce the risk of bone fractures associated with osteoporosis.

Those experiencing occasional muscle tension: Whether from exercise, daily activity, or occasional cramping, Magnesium oxide supports muscle relaxation. Magnesium deficiency is associated with muscle cramps, weakness, and impaired exercise performance.

People seeking nervous system support: Magnesium is fundamental to nervous system function, regulating neuronal excitability and neuromuscular transmission. This formula may be especially relevant for those looking to support calm, balanced nerve function.

Older adults: As we age, Magnesium absorption and retention can decrease, leading to deficiency and health consequences. Older people are more susceptible to Magnesium deficiency due to factors like decreased absorption from food and increased medication use.

Not sure if Magnesium oxide is right for your situation? We offer free naturopathic consultations — our naturopath can help you determine whether this formula fits your wellness goals.

Take 1 tablet daily with a meal.

Each bottle contains 180 tablets, providing a six-month supply at the recommended serving size of one tablet per day. Taking Magnesium oxide with food supports absorption and may reduce the likelihood of digestive discomfort.