Magnesium Chloride Guide | Benefits & Uses
Learn how Magnesium chloride supports nervous system health, bone density, and muscle relaxation. Explore key ingredients, benefits, and how to take it.
What Is Magnesium and Why Does It Matter?
Magnesium is the fourth most abundant cation in the human body and a critical cofactor in hundreds of enzymatic reactions that regulate energy metabolism, neuromuscular function, cardiovascular health, bone integrity, and psychological well-being. Nature's Sunshine Magnesium provides nervous system support and assists in a variety of bodily functions—making Magnesium chloride and related bioavailable forms essential daily nutrients.
Used by several hundred enzymes in their daily tasks, Magnesium is found in the bones, soft tissues, and blood. It helps metabolize various nutrients such as vitamin C, Phosphorus, potassium, and sodium. Research confirms that Magnesium is a cofactor in more than 300 enzyme systems that regulate protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation.
Despite Magnesium's essential roles, emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance—a deficiency problem contributing to various health conditions. If you're unsure whether your intake is adequate, our naturopath is available for a free consultation to help you assess your needs.
Nervous System, Bone Density, and Muscle Support
This formula is built around three core areas of support: nervous system health, bone density, and muscle cramps. Nature's Sunshine Magnesium comes in 250 mg capsules of Magnesium oxide and Magnesium amino acid chelate in a base of Licorice root, Kelp plant, Peppermint leaves, and White willow bark.
Magnesium is fundamental to nervous system function, acting as a natural NMDA receptor antagonist that modulates synaptic transmission and neuronal excitability. Research suggests that deficiency is associated with increased risk of neurological symptoms, and supplementation supports normal nerve function.
For bone density, Magnesium is an essential cofactor in bone mineral metabolism, enzyme activity for bone matrix synthesis, and is required for vitamin D activation. Observational data from large cohort studies found higher Magnesium intake associated with 2–3% greater bone density in women. Studies including the COMB study suggest supplementation may help attenuate bone loss.
Calcium and Magnesium are nutritional partners and work best when taken together. This formula includes both minerals, along with Phosphorus, to provide comprehensive skeletal and neuromuscular support.
Key Ingredients

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Who May Benefit from Magnesium Supplementation?
This formula may be a good fit for adults looking for everyday support in three interconnected areas: nervous system health, bone density, and muscle comfort. Since Magnesium is a cofactor in more than 300 enzyme systems, virtually every body system depends on adequate levels.
Research suggests that certain groups are more likely to have Magnesium inadequacy, including older adults (due to decreased absorption), individuals with gastrointestinal concerns, those with type 2 diabetes, and people on certain long-term medications such as diuretics or proton pump inhibitors. Men older than 70 and teenage girls are also most likely to have low intakes of Magnesium.
It is estimated that between 56 and 68% of Americans do not obtain enough Magnesium in their diet on a daily basis to meet the recommended daily allowance. If you're wondering whether Magnesium chloride or another form might be right for your situation, our naturopath offers free consultations to help you sort through the options.
How to Take Nature's Sunshine Magnesium
Take 1 tablet daily with a meal. Each bottle contains 180 tablets, providing a generous six-month supply at the recommended serving size of one tablet per day.
Because Calcium and Magnesium are nutritional partners and work best when taken together, this formula conveniently combines both minerals in a single tablet alongside Phosphorus and a supportive herbal base. Vitamin D and Magnesium help the body better absorb Calcium, so maintaining adequate vitamin D status may further support your results.
Written by Greg Howlett
Frequently asked questions
How does Magnesium chloride compare to other forms of Magnesium?
Magnesium supplements come in many forms. According to the NIH, forms of Magnesium that are more easily absorbed by the body include Magnesium aspartate, Magnesium citrate, Magnesium lactate, and Magnesium chloride. Inorganic forms such as Magnesium oxide tend to have lower solubility and absorption rates, while organic forms are generally more bioavailable. This Nature's Sunshine formula uses Magnesium oxide and Magnesium amino acid chelate.
Why are Calcium and Magnesium included together?
Calcium and Magnesium are nutritional partners that work best when taken together. Magnesium is required for vitamin D activation and Calcium metabolism, while Calcium is the primary mineral constituent of bone. Research suggests that adequate intake of both minerals supports bone density and proper muscle function. Magnesium also helps the body better absorb Calcium.
What are the signs of Magnesium deficiency?
Early signs may include loss of appetite, nausea, vomiting, fatigue, and weakness. As Magnesium deficiency worsens, numbness, tingling, muscle contractions and cramps, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur. It is estimated that between 56 and 68% of Americans do not obtain enough Magnesium daily to meet the recommended allowance.
Can Magnesium supplements interact with medications?
Yes. Magnesium can form insoluble complexes with tetracycline and quinolone antibiotics, reducing their absorption—these should be separated by at least 2 hours. It may also decrease absorption of bisphosphonates and gabapentin. Loop and thiazide diuretics can deplete Magnesium, and prolonged use of proton pump inhibitors (PPIs) can cause low Magnesium levels. Always consult a healthcare professional about potential interactions with your current medications.
Does this product support muscle cramp relief?
This formula is designed to support muscle comfort. Magnesium deficiency impairs muscle relaxation, as muscles contract normally but struggle to fully release when levels are low. Additionally, Calcium is recognized as essential for muscle contraction and relaxation—hypocalcemia (low Calcium) is a known cause of muscle cramps and spasms. Together, these minerals may support healthy muscle function.
How much Magnesium do adults need daily?
The Recommended Dietary Allowance (RDA) for Magnesium is 400–420 mg per day for adult men and 310–320 mg per day for adult women. During pregnancy, requirements increase to about 350–360 mg daily. This formula provides 250 mg of Magnesium per tablet. If you're unsure about your total daily intake, our naturopath is happy to help during a free consultation.
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