Best Magnesium Glycinate | Nervous System & Bone Support
Discover the best Magnesium glycinate for nervous system health, bone density, and muscle cramps. Learn about key ingredients, benefits, and how to take it.
Finding the Best Magnesium Glycinate for Everyday Wellness
Magnesium is the fourth most abundant cation in the human body and a critical cofactor in more than 300 enzyme systems that regulate energy metabolism, neuromuscular function, cardiovascular health, and bone integrity. Yet research suggests that between 56 and 68 percent of Americans do not obtain enough Magnesium in their daily diet to meet the Recommended Dietary Allowance.
When you're searching for the best Magnesium glycinate, you want a formula that not only delivers meaningful Magnesium but also pairs it with complementary nutrients and botanicals. Nature's Sunshine Magnesium provides 250 mg of Magnesium from both Magnesium oxide and Magnesium amino acid chelate, combined with Calcium, Phosphorus, and a supportive herbal base of Licorice root, Kelp, Peppermint leaves, and White willow bark β all in a convenient daily tablet.
This formula is designed to support nervous system health, bone density, and healthy muscle function. Magnesium helps metabolize various nutrients such as vitamin C, Phosphorus, potassium, and sodium, while Calcium and Magnesium work as nutritional partners that perform best when taken together.
Why This Formula Stands Out Among Magnesium Supplements
What sets the best Magnesium glycinate formulas apart is thoughtful ingredient pairing. Magnesium is required for energy production, oxidative phosphorylation, and glycolysis β it plays a pivotal role in ATP synthesis, the fundamental energy currency of every cell. It also modulates neuronal excitability through NMDA receptor blockade and voltage-gated Calcium antagonism, helping maintain calm nervous system function.
In this formula, Calcium and Magnesium are united as nutritional partners. Calcium is the most abundant mineral in the body, with over 99 percent stored in bone as hydroxyapatite. Research suggests that Calcium is essential for both skeletal and smooth muscle contraction. Meanwhile, Phosphorus β the second most abundant mineral in bone β forms hydroxyapatite alongside Calcium to provide bones and teeth with structural integrity and strength.
The herbal base adds traditional dimension. Licorice root has been used for over 4,000 years in traditional medicine systems worldwide, while Peppermint leaves have been valued since ancient Egyptian times for digestive comfort. White willow bark has been traditionally used for centuries in European and Native American herbal traditions for general aches and muscle soreness.
Key Ingredients

- β Free shipping over $75
- β 90-day easy returns
- β Ships within hours
Who Should Consider the Best Magnesium Glycinate
This formula may be a good fit for adults looking to support their nervous system, maintain healthy bone density, and promote comfortable muscle function. Because Magnesium is necessary for the function of over 300 enzymes, it touches virtually every body system β from energy production to proper elimination.
Older adults may find Magnesium support especially relevant. As we age, Magnesium absorption and retention can decrease, and older people are more susceptible to Magnesium deficiency due to factors like decreased absorption from food and increased medication use. Men older than 70 and teenage girls are identified as most likely to have low intakes.
If you're not sure whether a Magnesium supplement is right for your individual needs, our naturopath is available for a free consultation. We're happy to help you understand how Magnesium fits into your overall wellness routine.
How to Take This Magnesium Formula
Take 1 tablet daily with a meal. Each bottle contains 180 tablets, providing a generous six-month supply from a single bottle.
Taking Magnesium with food supports absorption and is gentler on the stomach. Because Calcium and Magnesium are nutritional partners that work best when taken together, this formula conveniently combines both minerals in a single tablet.
Written by Greg Howlett
Frequently asked questions
Why is this considered one of the best Magnesium glycinate options?
This Nature's Sunshine formula delivers 250 mg of Magnesium from both Magnesium oxide and Magnesium amino acid chelate, paired with complementary Calcium, Phosphorus, and a supportive herbal base. Magnesium amino acid chelate is absorbed via the dipeptide transporter pathway, and the formula is designed to support nervous system health, bone density, and muscle function. Magnesium glycinate is often recommended for individuals with sensitive digestive systems, as it tends to cause fewer gastrointestinal side effects.
What does Magnesium do in the body?
Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. It is required for energy production (ATP synthesis), is involved in bone formation, and modulates neuronal excitability through NMDA receptor blockade. It also supports proper elimination and helps metabolize various nutrients such as vitamin C, Phosphorus, potassium, and sodium.
Why are Calcium and Magnesium included together?
Calcium and Magnesium are nutritional partners that work best when taken together. Calcium is the primary mineral component of bone and is essential for muscle contraction and nerve transmission. Magnesium is involved in bone formation and influences the concentrations of parathyroid hormone and active vitamin D β both major regulators of Calcium metabolism and bone homeostasis. This formula includes 40 mg of Calcium alongside 250 mg of Magnesium.
How many servings are in a bottle?
Each bottle contains 180 tablets. The serving size is 1 tablet daily, so one bottle provides a full six-month supply.
Can Magnesium help with muscle cramps?
Magnesium is the most studied mineral supplement for skeletal muscle cramps. Magnesium deficiency impairs muscle relaxation β muscles may contract normally but struggle to fully release when levels are low. While Cochrane reviews found it unlikely to provide meaningful cramp prevention in older adults with idiopathic cramps, evidence for pregnancy-associated leg cramps remains conflicting. Adequate Magnesium intake supports overall healthy muscle function.
What herbs are included in the base and why?
The formula includes a base of Licorice root, Kelp plant, Peppermint leaves, and White willow bark. Licorice root has over 4,000 years of traditional use and appears in approximately 60% of traditional Chinese medicine prescriptions. Kelp provides naturally occurring minerals including iodine and has been used in traditional medicine for over 2,000 years. Peppermint leaves have been traditionally valued since ancient Egyptian times for digestive comfort. White willow bark has been used traditionally across European, Native American, and Chinese traditions for muscle soreness and general aches.
Talk to Dr. Shannyn Fowl
Not sure if this is right for you? Book a free, no-pressure consultation for personalized guidance on your health goals.
Book your free consult βAbout Caring Sunshine
A family-run reseller of premium supplements β free shipping, a 90-day guarantee, and real people who know the products.
Learn more about us β