Benefits of Magnesium | Nervous System & Bone Support
Discover the benefits of Magnesium for nervous system health, bone density, and muscle relaxation. Learn how this essential mineral supports over 300 enzymes.
Understanding the Benefits of Magnesium
Magnesium is the fourth most abundant cation in the human body and a critical cofactor in hundreds of enzymatic reactions that regulate energy metabolism, neuromuscular function, cardiovascular health, bone integrity, and psychological well-being. It is naturally present in many foods, available as a dietary supplement, and even found in some medicines such as antacids and laxatives.
Nature's Sunshine Magnesium provides nervous system support and assists in a variety of bodily functions. Used by several hundred enzymes in their daily tasks, Magnesium is found in the bones, soft tissues, and blood. It helps metabolize various nutrients such as vitamin C, Phosphorus, potassium, and sodium.
Despite Magnesium's essential roles, research suggests that between 56 and 68% of Americans do not obtain enough Magnesium in their diet on a daily basis to meet the recommended daily allowance. As we age, Magnesium absorption and retention can decrease, making supplementation an important consideration for many adults.
How Magnesium Supports Your Body
Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. It is required for energy production, oxidative phosphorylation, and glycolysis—the fundamental processes that keep every cell functioning.
In the nervous system, Magnesium modulates neuronal excitability through voltage-gated Calcium antagonism and N-methyl-D-aspartate (NMDA) receptor blockade. This helps regulate nerve signaling, synaptic transmission, and overall neurological stability.
For bone health, Magnesium is involved in bone formation and influences the activities of osteoblasts and osteoclasts. It also affects the concentrations of both parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis.
Calcium and Magnesium are nutritional partners and work best when taken together. This formula delivers both minerals alongside a supportive base of traditional herbs to promote proper absorption and utilization.
Key Ingredients

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Who May Benefit from Magnesium Supplementation
The benefits of Magnesium extend to a wide range of people. Because the diets of most Americans provide less than the recommended amounts of Magnesium, many adults could benefit from supplementation. Men older than 70 and teenage girls are most likely to have low intakes.
Individuals experiencing occasional muscle cramps or tension may find Magnesium particularly supportive, as it plays a direct role in muscle contraction and relaxation. Those focused on maintaining bone density may also benefit, since Magnesium influences osteoblast and osteoclast activity and is required for vitamin D activation.
Certain groups are more likely to have Magnesium inadequacy, including older adults (due to decreased absorption), individuals with gastrointestinal concerns, those with type 2 diabetes, and people on certain long-term medications such as diuretics or proton pump inhibitors.
If you're unsure whether Magnesium supplementation is right for you, our naturopath is available for a free consultation to help you evaluate your individual needs.
How to Take This Supplement
Take 1 tablet daily with a meal.
Nature's Sunshine Magnesium comes in 250 mg capsules of Magnesium oxide and Magnesium amino acid chelate. Each bottle contains 180 tablets. Taking Magnesium with food may support absorption and reduce the likelihood of digestive discomfort.
Written by Greg Howlett
Frequently asked questions
Why is Magnesium important for the body?
Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. It is required for energy production and is found in the bones, soft tissues, and blood. It also helps metabolize various nutrients such as vitamin C, Phosphorus, potassium, and sodium.
What are the signs of Magnesium deficiency?
Early signs and symptoms of Magnesium deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. As deficiency worsens, numbness, tingling, muscle contractions and cramps, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur. It is estimated that between 56 and 68% of Americans do not obtain enough Magnesium in their diet to meet the recommended daily allowance.
Can Magnesium help with muscle cramps?
Magnesium plays a direct role in muscle contraction and relaxation. Magnesium deficiency impairs muscle relaxation—muscles contract normally but struggle to fully release when levels are low. While Cochrane reviews of multiple RCTs found it unlikely to provide meaningful cramp prevention in older adults with idiopathic cramps, evidence for pregnancy-associated leg cramps remains mixed. Correcting a deficiency may support normal muscle function.
Does Magnesium support bone health?
Yes. Magnesium is involved in bone formation and influences the activities of osteoblasts and osteoclasts. It also affects the concentrations of both parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis. Observational data from large cohort studies have found higher Magnesium intake associated with greater bone mineral density. However, further research is needed to fully define its role in osteoporosis prevention.
Why does this formula include Calcium alongside Magnesium?
Calcium and Magnesium are nutritional partners and work best when taken together. Both minerals play essential roles in bone structure, muscle function, and nerve signaling. Calcium is the primary mineral in bone, while Magnesium is required for vitamin D activation and Calcium metabolism. This formula provides both minerals in a complementary ratio.
What forms of Magnesium are in this product?
Nature's Sunshine Magnesium contains Magnesium oxide and Magnesium amino acid chelate. Magnesium oxide is the most concentrated form by weight. Magnesium amino acid chelate involves Magnesium bound to amino acids, and the absorption of Magnesium chelated with amino acids has been observed via the dipeptide transporter pathway. The formula also includes a base of Licorice root, Kelp plant, Peppermint leaves, and White willow bark.
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