Adrenal Support | Vitamins, Herbs & Nutrients

Name: Adrenal Support
Brand: Nature's Sunshine
SKU: 1507
Price: 25.60 USD
Availability: InStock
Rating: 4.8 (37 reviews)

Discover how Adrenal Support nourishes adrenal glands with B vitamins, Vitamin C, Zinc, adaptogenic herbs & more. Learn about ingredients, benefits & usage.

Understanding the Formula

What Is Adrenal Support and Why It Matters

Nature's Sunshine Adrenal Support is specially formulated to nourish the adrenal glands with a combination of vitamins, minerals, enzymes, and adaptogenic herbs. The unique blend of herbs and nutrients in this formula assists the body in coping with stress by promoting healthy production of stress hormones from the adrenal gland.

Because stress hormones affect many bodily functions, Adrenal Support benefits cardiovascular and skin health, boosts energy levels, promotes positive moods, and encourages a healthy sex drive. When everyday demands pile up, your adrenals can become overtaxed, and giving them targeted nutritional support may help your body maintain balance.

This formula combines bovine adrenal gland substance, generous amounts of B vitamins and Vitamin C, plus Zinc, protease, Borage oil powder, Licorice root, and schizandra fruit — each chosen for a specific role in supporting normal adrenal function and helping regulate the stress response.

How It Works

Supporting the HPA Axis and Stress Response

Your hypothalamic-pituitary-adrenal (HPA) axis is the central control system for your body's stress response. When this system is under constant strain, cortisol production, energy levels, and mood can all be affected. Adrenal Support works by supplying the raw materials — vitamins, minerals, and botanicals — that the adrenal glands need to manufacture stress hormones efficiently.

Research suggests that Vitamin C is the most concentrated nutrient in the adrenal cortex and serves as an essential cofactor for cortisol and catecholamine synthesis. Similarly, pantothenic acid (Vitamin B5) is the rate-limiting cofactor for coenzyme A biosynthesis, which drives the first step of adrenal steroidogenesis — the conversion of cholesterol to pregnenolone. Together with Vitamin B6, thiamin, riboflavin, Zinc, and Magnesium, these nutrients form a comprehensive micronutrient foundation for adrenal health.

The adaptogenic herbs in the formula — schizandra fruit and Licorice root — complement the vitamins and minerals by helping modulate HPA axis activity. Studies suggest that Schisandrins from Schisandra chinensis may suppress cortisol release and reduce stress-induced fatigue, while glycyrrhizin from Licorice root inhibits the enzyme 11β-HSD2 that inactivates cortisol, thereby prolonging cortisol availability in tissues.

What's inside

Key Ingredients

Vitamin C — 25 mg

The adrenal glands contain 20–150 times more Vitamin C than most body tissues. Vitamin C is a required cofactor for both cortisol and catecholamine synthesis, and research suggests that acute stress can deplete adrenal Vitamin C stores within hours. A human randomized controlled trial found that 500 mg/day significantly reduced cortisol, blood pressure, and subjective stress in participants exposed to psychological stressors. In this formula, Vitamin C provides foundational support for the adrenal cortex's hormone-manufacturing machinery.

thiamin — 10 mg

Thiamin (Vitamin B1) is the precursor for the coenzyme thiamine diphosphate (ThDP), which is indispensable for oxidative energy metabolism. ThDP is a cofactor for pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, and transketolase — enzymes that allow for the production of ATP, NADPH, and ribose-5-phosphate. Thiamin also plays a role in muscle contraction, conduction of nerve signals, and proper functioning of the central and peripheral nervous system, where it supports neurotransmitter synthesis.

riboflavin — 5 mg

Riboflavin (Vitamin B2) is an essential component of two major coenzymes — flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes play major roles in energy production, cellular function and growth, and the metabolism of fats, drugs, and steroids. FAD is also required by the flavoprotein methylenetetrahydrofolate reductase (MTHFR), which is pivotal in folate-mediated one-carbon metabolism, and FMN is needed for the conversion of Vitamin B6 to its active coenzyme form.

Vitamin B6 — 5 mg

Vitamin B6 is an essential cofactor in neurotransmitter biosynthesis pathways for serotonin, dopamine, GABA, and norepinephrine — neurotransmitters that regulate HPA axis activity. Research suggests that high-dose Vitamin B6 significantly reduced self-reported stress and anxiety in a clinical trial of 478 young adults. Its role as a rate-limiting cofactor for inhibitory neurotransmitter production makes it mechanistically central to stress modulation and Adrenal Support.

pantothenic acid — 45 mg

Pantothenic acid (Vitamin B5) is the direct precursor to coenzyme A (CoA), which is required for the enzymatic conversion of cholesterol to pregnenolone — the rate-limiting step of adrenal steroidogenesis that produces cortisol, DHEA, and aldosterone. The adrenal cortex maintains very high concentrations of B5 to support these CoA-dependent steps. Animal studies show that pantothenic acid deficiency causes adrenal atrophy and impairs the adrenal stress response. Traditionally known in nutritional medicine as the 'anti-stress vitamin,' B5 is consistently included in functional medicine Adrenal Support protocols.

Magnesium — 10 mg

Magnesium directly modulates adrenal function by regulating the HPA axis and limiting cortisol and catecholamine release under stress. Research suggests that deficiency increases ACTH release, elevates stress hormones, and worsens anxiety, while chronic stress itself depletes Magnesium — creating a feedback cycle that may exacerbate adrenal fatigue symptoms. Magnesium also modulates NMDA glutamate receptors and supports GABAergic availability, reducing neuronal excitability. A systematic review of 18 studies found consistent evidence that supplementation reduces subjective anxiety, particularly in vulnerable populations.

Zinc — 5 mg

Zinc is required for the synthesis of adrenal hormones and acts as a cortisol modulator. Research suggests that Zinc deficiency is associated with elevated cortisol and HPA axis dysregulation, while supplementation may modulate ACTH/cortisol output and support DHEA production — both key features of adrenal health management. Zinc is also a cofactor for over 300 enzymes spanning immune regulation, DNA synthesis, and protein metabolism.

Potassium — 5 mg

Potassium is the primary intracellular cation, essential for maintaining proper electrolyte balance, nerve signaling, and muscle contraction. The Na⁺/K⁺-ATPase activity is stimulated by both insulin and aldosterone, linking Potassium homeostasis to adrenal mineralocorticoid signaling. Even a small amount of Potassium helps support cellular function and electrochemical balance across the body's tissues.

schisandra fruit — 240 mg

Schisandra chinensis is a classical adaptogen used in Traditional Chinese Medicine for over 1,700 years. Its active compounds — Schisandrins — are bioactive lignans that research suggests may suppress cortisol release, reduce stress-induced fatigue, and support hepatic cortisol metabolism. In TCM it is known as Wu Wei Zi ('five flavors fruit') and is valued for 'quieting the spirit and calming the heart.' Preclinical studies show Schisandrins reduce hypothalamic CRH expression and modulate HPA axis activity, and the herb is included in systematic reviews of adaptogens with clinical-level evidence for stress support.

Borage seed oil — 240 mg

Borage seed oil is the richest plant source of gamma-linolenic acid (GLA), an essential fatty acid. GLA is metabolized to dihomo-gamma-linolenic acid (DGLA), the precursor of anti-inflammatory prostaglandin E1 (PGE1). Borage has a well-established traditional reputation in Western herbalism as an adrenal cortex restorative, particularly after periods of chronic stress or following steroid therapy. Multiple herbal monographs record this traditional use for adrenal renewal.

Licorice root — 240 mg

Licorice root's active compound glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which converts active cortisol to inactive cortisone. By slowing this conversion, Licorice root prolongs cortisol bioavailability in tissues — a mechanism directly relevant to supporting the body during periods of low-cortisol adrenal fatigue. Research published in <em>Molecular and Cellular Endocrinology</em> has documented this mechanism, and Licorice root has been used in both TCM and Ayurveda for Adrenal Support and fatigue for thousands of years.

Adrenal Support

★★★★★ 4.8 (37 reviews)

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Adrenal Support

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Is It Right for You?

Who May Benefit from Adrenal Support

Adrenal Support is designed for adults who are looking to nourish their adrenal glands and help their body cope with everyday stress. If you experience persistent fatigue, low energy, mood fluctuations, or feel that prolonged stress has taken a toll on your vitality, this formula may be worth exploring.

People dealing with demanding schedules, high-pressure work environments, or periods of physical and emotional strain may find the combination of B vitamins, Vitamin C, Zinc, Magnesium, and adaptogenic herbs particularly relevant. The formula promotes the healthy manufacture of stress hormones while also supporting cardiovascular health, skin health, positive moods, and a healthy sex drive.

If you're unsure whether Adrenal Support is appropriate for your situation, our naturopath offers free consultations and can help you determine whether this formula aligns with your individual wellness goals.

Usage Guidelines

How to Take Adrenal Support

Take 1 capsule with a meal twice daily. Each bottle contains 60 capsules, providing a full 30-day supply at the recommended serving.

Taking the capsules with food helps support absorption of the fat-soluble Borage oil component and may reduce any potential digestive sensitivity. For personalized guidance on incorporating Adrenal Support into your daily wellness routine, feel free to reach out to our naturopath for a free consultation.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What does Adrenal Support do?

Adrenal Support is specially formulated to nourish the adrenal glands with a combination of vitamins, minerals, enzymes, and adaptogenic herbs. It supports normal adrenal function, assists in regulating stress, and promotes the healthy manufacture of stress hormones. Because stress hormones affect many bodily functions, the formula also benefits cardiovascular and skin health, boosts energy levels, promotes positive moods, and encourages a healthy sex drive.

What ingredients are in Adrenal Support?

The formula includes bovine adrenal gland substance, vitamins B1 (thiamin), B2 (riboflavin), B6, pantothenic acid (B5), and Vitamin C, along with Zinc, Magnesium, Potassium, protease, Borage seed oil, Licorice root, and schizandra fruit. Each ingredient was chosen for its specific role in supporting adrenal gland function and the body's stress response.

How do I take Adrenal Support?

Take 1 capsule with a meal twice daily. Each bottle contains 60 capsules, so one bottle lasts a full month at the recommended serving size.

Why are B vitamins important for adrenal health?

B vitamins play essential roles in adrenal function. Pantothenic acid (B5) is the direct precursor to coenzyme A, which drives the first step of adrenal steroid hormone synthesis. Vitamin B6 is a cofactor for neurotransmitter production (serotonin, dopamine, GABA) that regulates HPA axis activity. Thiamin and riboflavin support energy production through their coenzyme roles in carbohydrate and fat metabolism, providing the cellular energy the adrenal glands need to function.

What role do schizandra fruit and Licorice root play in this formula?

Schizandra fruit is a classical adaptogen with over 1,700 years of use in Traditional Chinese Medicine. Research suggests its active lignans (Schisandrins) may help modulate HPA axis activity and reduce stress-induced fatigue. Licorice root contains glycyrrhizin, which research shows inhibits the enzyme that inactivates cortisol, thereby prolonging cortisol's availability in the body — an action relevant to supporting adrenal function during stress.

Can I get personalized advice about Adrenal Support?

Absolutely. We offer free naturopathic consultations, so you can speak directly with our naturopath to discuss your individual situation and find out whether this formula is right for you.

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