Adrenal Support Supplements | Nature’s Sunshine

Name: Adrenal Support
Brand: Nature's Sunshine
SKU: 1507
Price: 25.60 USD
Availability: InStock
Rating: 4.8 (37 reviews)

Learn how Adrenal Support supplements with adaptogens, B vitamins, Vitamin C, and Zinc nourish your adrenal glands and help your body cope with everyday stress.

Understanding Adrenals

What are Adrenal Support supplements and why do they matter?

Your adrenal glands sit atop each kidney and produce stress hormones — including cortisol and catecholamines — that influence everything from energy levels and mood to cardiovascular function and skin health. When everyday demands pile up, these small but mighty glands can become overtaxed, potentially leaving you feeling fatigued, foggy, or emotionally drained.

Adrenal Support supplements are specially formulated to nourish the adrenal glands with a targeted combination of vitamins, minerals, enzymes, and adaptogenic herbs. Nature's Sunshine Adrenal Support is designed to assist the body in coping with stress by promoting healthy production of stress hormones from the adrenal gland. Because stress hormones affect so many bodily functions, this formula may also benefit cardiovascular and skin health, boost energy levels, promote positive moods, and encourage a healthy sex drive.

If you're unsure whether an Adrenal Support supplement fits your wellness goals, our naturopath is available for a free consultation to help you explore your options.

How It Works

How Adrenal Support supplements nourish the stress response

The hypothalamic-pituitary-adrenal (HPA) axis is the communication pathway your body uses to manage stress. When the brain perceives a stressor, the hypothalamus signals the pituitary gland, which in turn triggers the adrenal cortex to release cortisol and other hormones. Chronic stress can disrupt this feedback loop, depleting the nutrients your adrenal glands depend on to function properly.

Nature's Sunshine Adrenal Support takes a multi-pronged approach. It supplies generous amounts of key B vitamins and Vitamin C — nutrients the adrenal cortex concentrates at levels far above most other tissues — to serve as cofactors for cortisol and catecholamine synthesis. It adds Zinc and Magnesium, minerals that help modulate HPA axis activity. And it rounds out the formula with adaptogenic herbs like schisandra fruit and Licorice root, plus bovine adrenal gland substance and Borage oil powder, creating a comprehensive blend that addresses adrenal health from multiple angles.

What's inside

Key ingredients

Vitamin C — 25 mg

The adrenal glands contain 20–150 times more Vitamin C than most body tissues, making it the most concentrated nutrient in the adrenal cortex. Vitamin C is a required cofactor for both cortisol and catecholamine synthesis, and research suggests that acute stress can deplete adrenal Vitamin C within hours. A human randomized controlled trial found that 500 mg/day of Vitamin C significantly reduced cortisol, blood pressure, and subjective stress in participants exposed to psychological stressors. In addition to its adrenal role, Vitamin C is a potent water-soluble antioxidant that supports collagen synthesis, immune defense, and iron absorption.

thiamin — 10 mg

Thiamin (Vitamin B1) is the precursor to thiamine pyrophosphate (TPP), a coenzyme that drives energy production through the pyruvate dehydrogenase complex, the TCA cycle, and the pentose phosphate pathway. Because the adrenal glands have high metabolic demands during stress, adequate thiamin is essential for generating the cellular energy that fuels hormone production. Thiamin also plays a role in muscle contraction, nerve signal conduction, and neurotransmitter synthesis, all of which may be affected when the body is under chronic stress.

riboflavin — 5 mg

Riboflavin (Vitamin B2) is converted into the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which participate in energy production, cellular growth, and the metabolism of fats, drugs, and steroids. FAD is also required for the conversion of other B vitamins — including B6 and folate — into their active forms, making riboflavin a linchpin in the broader B-vitamin network that supports adrenal function. Additionally, riboflavin helps maintain the integrity of the nervous system, red blood cell production, and healthy skin and mucous membranes.

Vitamin B6 — 5 mg

Vitamin B6 (pyridoxine) serves as an essential cofactor in the biosynthesis of serotonin, dopamine, GABA, and norepinephrine — neurotransmitters that directly regulate HPA axis activity and the adrenal stress response. Research suggests that deficiency impairs adrenal function, and a clinical trial of 478 young adults found that high-dose Vitamin B6 significantly reduced self-reported stress and anxiety. The 2025 American Journal of Medicine lists B6 among the key micronutrients for HPA axis support alongside B5, Magnesium, Zinc, and Vitamin C.

pantothenic acid — 45 mg

Pantothenic acid (Vitamin B5) is the direct precursor to coenzyme A (CoA), which catalyzes the rate-limiting step of adrenal steroidogenesis — the conversion of cholesterol to pregnenolone, the master precursor of cortisol, aldosterone, and DHEA. The adrenal cortex maintains very high concentrations of pantothenic acid to sustain this process. Animal studies dating from the 1950s demonstrated that B5 depletion impairs adrenal structure and stress response, and chronic stress is believed to increase B5 demand. It is consistently cited in integrative medicine as a core adrenal-support nutrient and has been traditionally referred to as the 'anti-stress vitamin.'

Magnesium — 10 mg

Magnesium is a cofactor in more than 300 enzyme systems, including those governing ATP production, cortisol regulation, and nervous system function. Research suggests that Magnesium directly modulates HPA axis activity: deficiency enhances the release of CRH, ACTH, and cortisol, while chronic stress depletes Magnesium — creating a feedback cycle that may worsen adrenal fatigue symptoms. A systematic review of 18 studies found beneficial effects of supplementation on subjective anxiety, particularly in vulnerable populations. The 2025 American Journal of Medicine review recommends 300–400 mg/day of Magnesium for HPA axis support during stress.

Zinc — 5 mg

Zinc is required for adrenal steroidogenesis and serves as a cortisol modulator. Research in animal models indicates that Zinc deficiency elevates serum cortisol levels and enhances HPA axis activity, while supplementation supports DHEA production and modulates excessive cortisol output. The 2025 American Journal of Medicine review identifies Zinc deficiency as impairing adrenal and neuroendocrine function. Zinc is also a component of more than 300 enzymes and plays critical roles in immune defense, DNA synthesis, and wound healing.

Potassium — 5 mg

Potassium is an essential electrolyte that maintains cell membrane potential, supports proper muscle and nerve function, and helps regulate blood pressure through its interaction with sodium. The Na⁺/K⁺-ATPase pump — stimulated by both insulin and aldosterone — keeps intracellular and extracellular ion gradients in balance, a process fundamental to every cell in the body. Adequate Potassium intake supports overall electrolyte equilibrium, which is particularly relevant when the adrenal glands are actively managing the body's stress response.

schisandra fruit — 240 mg

Schisandra chinensis (Wu Wei Zi, or 'five flavors fruit') is a classical adaptogen used in Traditional Chinese Medicine for over 1,700 years for stress resilience, fatigue, and emotional stability. Its principal bioactive compounds — the dibenzocyclooctadiene lignans known as Schisandrins — have been studied for their ability to support HPA axis function. Animal studies show that schisandra extracts reduce hypothalamic CRH expression and suppress cortisol release under stress, while clinical trials document anti-fatigue effects and improvements in mental work capacity against a background of stress and exhaustion. In TCM, Wu Wei Zi is traditionally prescribed to 'quiet the spirit and calm the heart.'

Borage seed oil — 240 mg

Borage seed oil is the richest plant source of gamma-linolenic acid (GLA), an omega-6 fatty acid that the body converts to anti-inflammatory prostaglandins of the 1-series. Borage has a well-established traditional reputation in Western herbalism as an adrenal cortex restorative, historically used after periods of chronic stress or corticosteroid therapy to help renew adrenal gland function. Multiple herbal monographs record this use, and the plant's Latin motto — <em>Ego borago gaudia semper ago</em> ('I, Borage, bring always courage') — speaks to its longstanding association with vitality and resilience.

Licorice root — 240 mg

Licorice root (Glycyrrhiza glabra) has been used for over 4,000 years across Assyrian, Egyptian, Greek, and Chinese medical traditions. Its primary active compound, glycyrrhizin, inhibits the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which converts active cortisol to inactive cortisone. By slowing this conversion, Licorice root may prolong cortisol bioavailability in tissues — a mechanism directly relevant to low-cortisol states associated with adrenal fatigue. Research published in the journal <em>Steroids</em> confirmed increases in salivary DHEA, deoxycorticosterone, and testosterone after licorice consumption. The VA Whole Health Library and integrative medicine sources identify it as a key adrenal-supportive herb.

Adrenal Support

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Adrenal Support

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Who Benefits

Who may benefit from Adrenal Support supplements?

Adrenal Support supplements like this formula may be a fit for adults who experience persistent, everyday stress and want to nourish their body's natural stress-management systems. You might consider Adrenal Support if you:

Feel chronically fatigued despite adequate sleep
Notice your energy drops sharply in the afternoon
Feel mentally foggy or have difficulty concentrating under pressure
Want to promote positive moods and emotional resilience during demanding periods
Are looking for nutritional support for healthy cortisol and stress hormone production

Because this formula contains bovine adrenal gland substance and adaptogenic herbs, it's always a good idea to discuss it with a knowledgeable practitioner before starting. Our naturopath offers free consultations and can help you decide whether Adrenal Support is right for your individual situation.

Directions

How to take Nature's Sunshine Adrenal Support

Take 1 capsule with a meal twice daily. Each bottle contains 60 capsules, providing a full 30-day supply at the recommended serving size of 1 capsule per dose.

Taking each capsule with food helps support absorption of the fat-soluble Borage oil component and may improve overall tolerance of the B vitamins and minerals in the formula.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What does Adrenal Support do?

Nature's Sunshine Adrenal Support is specially formulated to nourish the adrenal glands with a combination of vitamins, minerals, enzymes, and adaptogenic herbs. It assists the body in coping with stress by promoting healthy production of stress hormones from the adrenal gland. Because stress hormones affect many bodily functions, the formula also supports cardiovascular and skin health, boosts energy levels, promotes positive moods, and encourages a healthy sex drive.

Why are B vitamins important for adrenal health?

Several B vitamins play direct roles in adrenal function. Pantothenic acid (B5) is the precursor to coenzyme A, which drives the first step of adrenal steroid hormone synthesis. Vitamin B6 is an essential cofactor for neurotransmitter production (serotonin, dopamine, GABA) that regulates HPA axis activity. Thiamin (B1) and riboflavin (B2) support the energy metabolism pathways the adrenal glands depend on for hormone production.

How does Licorice root support the adrenals?

Licorice root contains glycyrrhizin, which inhibits the enzyme 11β-HSD2 that converts active cortisol to inactive cortisone. By slowing this conversion, Licorice root may help prolong cortisol availability in tissues — a mechanism that research suggests is relevant in low-cortisol states associated with adrenal fatigue.

What is schisandra fruit and why is it in this formula?

Schisandra chinensis is an adaptogenic herb used in Traditional Chinese Medicine for over 1,700 years. Its bioactive lignans, called Schisandrins, have been studied for their ability to modulate HPA axis function, suppress excess cortisol release under stress, and reduce fatigue. Clinical trials have documented improvements in mental work capacity against a background of stress and exhaustion.

Can I take Adrenal Support supplements long-term?

This formula is designed to be taken on an ongoing basis as part of your daily wellness routine — 1 capsule with a meal twice daily. As with any supplement, it's wise to check in with a qualified practitioner periodically. Our naturopath is available for a free consultation if you'd like personalized guidance on long-term use.

Does this product contain any animal-derived ingredients?

Yes. Nature's Sunshine Adrenal Support includes bovine adrenal gland substance as part of its formula, in addition to plant-based ingredients like schisandra fruit, Borage oil powder, and Licorice root.

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