Adrenal Support Supplement | Nature’s Sunshine 1507

Name: Adrenal Support
Brand: Nature's Sunshine
SKU: 1507
Price: 25.60 USD
Availability: InStock
Rating: 4.8 (37 reviews)

Discover how Nature's Sunshine Adrenal Support nourishes your adrenal glands with vitamins, minerals, adaptogenic herbs, and bovine adrenal gland tissue for healthy stress response.

Overview

What Is an Adrenal Support Supplement?

Your adrenal glands sit atop each kidney and produce the stress hormones that influence everything from cardiovascular function and energy levels to mood, skin health, and sex drive. When chronic stress taxes these small but powerful glands, the body's ability to manufacture and regulate stress hormones can falter — a pattern often described in integrative medicine as adrenal fatigue or HPA (hypothalamic-pituitary-adrenal) axis dysfunction.

Nature's Sunshine Adrenal Support is specially formulated to nourish the adrenal glands with a targeted combination of vitamins, minerals, enzymes, and adaptogenic herbs. This Adrenal Support supplement assists the body in coping with stress by promoting healthy production of stress hormones from the adrenal gland. Because stress hormones affect so many bodily functions, the formula is designed to support normal adrenal function, assist in regulating the stress response, and promote the manufacture of stress hormones.

If you have questions about whether an Adrenal Support supplement fits your wellness goals, our naturopath is available for a free consultation — no membership or commitment required.

How It Works

Supporting the Adrenal Glands and HPA Axis

The HPA axis is the body's central stress-response system, connecting the hypothalamus, pituitary gland, and adrenal cortex in a tightly regulated hormonal cascade. When this axis is overburdened by ongoing stress, key nutrients can become depleted — particularly Vitamin C, B vitamins, Magnesium, and Zinc — all of which serve as essential cofactors for cortisol biosynthesis and neurotransmitter production.

Nature's Sunshine Adrenal Support addresses this from multiple angles. It supplies bovine adrenal gland tissue alongside generous amounts of vitamins B1, B2, B6, pantothenic acid, and Vitamin C to feed the enzymatic pathways that produce adrenal hormones. Zinc and Magnesium round out the mineral support, while the adaptogenic herbs schisandra fruit and Licorice root help modulate the body's stress response. Borage oil powder and protease enzyme complete the formula.

Each capsule delivers a synergistic blend that works together to keep your stress-response machinery properly nourished rather than addressing a single pathway in isolation.

What's inside

Key Ingredients

Vitamin C — 25 mg

Vitamin C (ascorbic acid) is a water-soluble antioxidant and a required cofactor for cortisol and catecholamine synthesis. The adrenal glands contain 20–150 times more Vitamin C than most body tissues, making it one of the most concentrated nutrients in the adrenal cortex. Research shows that acute stress depletes adrenal Vitamin C within hours. A human randomized controlled trial found that 500 mg/day of Vitamin C significantly reduced cortisol, blood pressure, and subjective stress in participants exposed to psychological stressors. In this formula, Vitamin C provides foundational support for adrenal cortex and medulla function.

Thiamin (Vitamin B1) — 10 mg

Thiamin is the precursor to thiamine diphosphate (ThDP), a coenzyme indispensable for oxidative energy metabolism. ThDP serves as a cofactor for pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase — enzymes involved in generating the cellular ATP that fuels adrenal hormone production and nervous system function. Thiamin also plays a role in muscle contraction, nerve signal conduction, and neurotransmitter synthesis. It helps the body's cells change carbohydrates into energy, providing fuel for the brain and nervous system during periods of stress.

Riboflavin (Vitamin B2) — 5 mg

Riboflavin is an essential component of two major coenzymes — flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) — that play central roles in energy production, cellular function, and metabolism of fats, drugs, and steroids. FAD is also necessary for converting Vitamin B6 to its active coenzyme form pyridoxal 5′-phosphate, meaning riboflavin status directly affects the activation of other B vitamins in this formula. Riboflavin supports energy metabolism and helps maintain the integrity of the nervous system.

Vitamin B6 — 5 mg

Vitamin B6, as its active form pyridoxal 5′-phosphate (PLP), is the essential coenzyme for decarboxylation reactions that produce serotonin, dopamine, GABA, and norepinephrine — neurotransmitters that regulate HPA axis activity and mood. Research suggests that deficiency impairs adrenal function, and B6 is identified in the 2025 American Journal of Medicine's list of key micronutrients for HPA axis support. A clinical trial of 478 young adults found that high-dose Vitamin B6 significantly reduced self-reported stress and anxiety, consistent with its mechanistic role as a rate-limiting cofactor for inhibitory neurotransmitter production.

Pantothenic Acid (Vitamin B5) — 45 mg

Pantothenic acid is the direct precursor to coenzyme A (CoA), which drives the first and rate-limiting step of adrenal steroidogenesis — the conversion of cholesterol to pregnenolone, which is then converted to cortisol, DHEA, and aldosterone. The adrenal cortex maintains very high concentrations of B5 to support these CoA-dependent enzymatic steps. Animal studies from the 1950s onward showed that pantothenic acid depletion impairs the adrenal stress response and causes adrenal atrophy. Traditionally recognized in nutritional medicine as the 'anti-stress vitamin,' B5 is consistently included in integrative HPA axis support protocols.

Magnesium — 10 mg

Magnesium directly modulates HPA axis activity by regulating NMDA receptor-mediated excitatory neurotransmission and enhancing GABAergic availability. Research shows that deficiency increases ACTH release and elevates stress hormones, while chronic stress itself depletes Magnesium — creating a feedback cycle that may worsen adrenal fatigue symptoms. A systematic review of 18 studies found consistent evidence that Magnesium supplementation reduces subjective anxiety, particularly in vulnerable populations, and the 2025 American Journal of Medicine review recommends 300–400 mg/day for HPA axis support during stress.

Zinc — 5 mg

Zinc is required for adrenal steroidogenesis and serves as a cortisol modulator. Research supports Zinc's role in supporting DHEA production and modulating excessive cortisol output — both key features of adrenal fatigue management. The 2025 American Journal of Medicine review identifies Zinc deficiency as impairing adrenal and neuroendocrine function. In animal models, deficiency specifically enhances HPA axis activity and elevates glucocorticoid secretion. Adequate Zinc status is necessary for normal hypothalamic-pituitary neuroendocrine function.

Potassium — 5 mg

Potassium is an essential electrolyte that maintains normal cellular function through the sodium-Potassium pump — a transport system critical for nerve signaling, muscle contraction, and blood pressure regulation. Potassium homeostasis is influenced by aldosterone, a mineralocorticoid hormone produced by the adrenal cortex, linking Potassium balance directly to adrenal function. Even a small amount of supplemental Potassium supports the electrolyte balance that healthy adrenal output depends upon.

Schisandra Fruit — 240 mg

Schisandra chinensis (Wu Wei Zi, or 'five flavors fruit') is a classical adaptogen used in Traditional Chinese Medicine and Russian phytomedicine for over 1,700 years for fatigue, stress, and neuroendocrine regulation. Its active lignan compounds — the Schisandrins — have been studied for their ability to modulate HPA axis function, suppress stress-induced cortisol release, and support hepatic cortisol metabolism. Animal studies show that schisandra extracts reduce hypothalamic CRH mRNA expression under stress conditions. Clinical trials using Schisandra chinensis on mental performance suggest anti-fatigue effects and increased mental work capacity against a background of stress.

Borage Seed Oil — 240 mg

Borage seed oil is the richest plant source of gamma-linolenic acid (GLA), an essential fatty acid involved in the production of anti-inflammatory prostaglandins. In Western herbal medicine, Borage has a well-established traditional reputation as an adrenal cortex restorative, used particularly after periods of chronic stress or following corticosteroid therapy. Multiple herbal monographs record this traditional application, and the inclusion of Borage oil in an Adrenal Support supplement reflects this longstanding use in supporting adrenal gland renewal.

Licorice root — 240 mg

Licorice root (Glycyrrhiza glabra) has well-documented effects on adrenal cortisol metabolism. Its active compound glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which converts active cortisol to inactive cortisone. By slowing this conversion, Licorice root extends cortisol bioavailability in tissues — a mechanism directly relevant to low-cortisol states. Research published in Steroids confirmed increases in salivary DHEA, deoxycorticosterone, and testosterone after licorice consumption. Licorice root has been used in Traditional Chinese Medicine for centuries, appearing in approximately 60% of TCM prescriptions.

Adrenal Support

★★★★★ 4.8 (37 reviews)

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Adrenal Support

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Who Benefits

Who May Benefit from an Adrenal Support Supplement?

This Adrenal Support supplement is designed for adults who are navigating periods of ongoing or recurring stress and want to nourish their adrenal glands nutritionally. Because stress hormones affect so many bodily functions, the formula may be particularly relevant for those looking to support cardiovascular health, promote positive moods, maintain healthy energy levels, encourage skin health, or support a healthy sex drive — all areas influenced by adrenal hormone output.

People who feel their stress-response system has been working overtime — whether from work demands, life transitions, or simply the pace of modern living — may find that an Adrenal Support supplement helps fill nutritional gaps that chronic stress can create.

Not sure if this formula is right for you? Our naturopath offers free consultations to help you determine which supplements align with your individual needs.

Directions

How to Take Adrenal Support

Take 1 capsule with a meal twice daily. Each bottle contains 60 capsules, providing a full 30-day supply at the recommended serving.

Taking the capsules with meals helps support absorption of the fat-soluble components like Borage seed oil and may reduce any potential digestive sensitivity from the herbal ingredients.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What does an Adrenal Support supplement actually do?

Nature's Sunshine Adrenal Support nourishes the adrenal glands with a targeted blend of vitamins, minerals, enzymes, and adaptogenic herbs. The formula assists the body in coping with stress by promoting healthy production of stress hormones from the adrenal gland. Because stress hormones affect many bodily functions, it also supports cardiovascular and skin health, boosts energy levels, promotes positive moods, and encourages a healthy sex drive.

What key nutrients support adrenal function?

This formula includes bovine adrenal gland tissue, generous amounts of vitamins B1, B2, B6, pantothenic acid, and Vitamin C, plus Zinc, Magnesium, and Potassium. Pantothenic acid is the direct precursor to coenzyme A needed for cortisol synthesis, Vitamin C is found in uniquely high concentrations in the adrenal glands, and B6 is essential for neurotransmitter production that regulates the HPA axis. These are rounded out by the adaptogenic herbs schisandra fruit and Licorice root, along with Borage oil powder and protease enzyme.

What is the HPA axis and how does it relate to adrenal fatigue?

The HPA (hypothalamic-pituitary-adrenal) axis is the body's central stress-response system. It coordinates the release of stress hormones like cortisol from the adrenal glands. When chronic stress overtaxes this system, key nutrients — including Vitamin C, B vitamins, Magnesium, and Zinc — may become depleted, potentially impairing the adrenal glands' ability to respond effectively. Adrenal Support provides these cofactors along with adaptogenic herbs that research suggests may help modulate HPA axis activity.

How does Licorice root support the adrenals?

Licorice root contains glycyrrhizin, which inhibits the enzyme 11β-HSD2 that converts active cortisol into inactive cortisone. By slowing this conversion, Licorice root helps extend cortisol availability in the body — a mechanism especially relevant in low-cortisol states. It has been used in Traditional Chinese Medicine for centuries and appears in approximately 60% of TCM prescriptions.

Is schisandra fruit an adaptogen?

Yes. Schisandra chinensis (Wu Wei Zi) is classified as an adaptogen in both Traditional Chinese Medicine and Russian phytomedicine. Its active lignan compounds — the Schisandrins — have been studied for their ability to modulate HPA axis function, reduce stress-induced fatigue, and support mental performance under stress. It has been used for over 1,700 years for fatigue, stress, and neuroendocrine regulation.

Can I talk to someone about whether this Adrenal Support supplement is right for me?

Absolutely. We offer free naturopathic consultations with our naturopath — no membership required, no obligation. Our naturopath can review your individual health goals and help you determine whether Adrenal Support is a good fit for your needs.

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