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What Is Ashwagandha? Benefits, Ingredients & More

Learn what Ashwagandha is, how this adaptogenic blend supports stress, performance, and cognition, plus key ingredients, directions, and FAQs.

Overview

What Is Ashwagandha?

If you've been exploring natural ways to manage stress, sharpen mental focus, or support physical performance, you've likely come across the question: what is Ashwagandha? Ashwagandha (Withania somnifera) is a small shrub in the Solanaceae (nightshade) family, native to the Indian subcontinent and also found in parts of southern Europe, Africa, and Australia. Its name comes from Sanskrit, translating to "smell of a horse" — a reference to the herb's distinctive aroma and its traditional reputation for imparting vigor and strength.

Ashwagandha has been used in Ayurvedic and indigenous medicine for over 3,000 years, where it is classified as a Rasayana — an herbal preparation described as promoting a youthful state of physical and mental health. It appears in the foundational Ayurvedic texts Charaka Samhita and Susruta Samhita, where it was prescribed for stress, fatigue, pain, and general vitality.

This particular formula goes beyond Ashwagandha alone. It's a unique adaptogenic blend combining standardized extracts of Ashwagandha root, Bacopa leaf, Rhodiola root, and Schisandra fruit, plus Black pepper fruit extract. Adaptogens are a class of botanicals traditionally recognized for their ability to help your body adapt to environmental stressors — supporting your stress response, cognitive performance, physical endurance, and overall well-being.

If you're curious about which adaptogenic herbs might be right for your needs, our naturopath offers free consultations to help you sort through the options.

How It Works

How This Adaptogenic Blend Supports Your Body

Understanding what Ashwagandha is begins with understanding how it works. The bioactive compounds in Ashwagandha — primarily withanolides — modulate the hypothalamic-pituitary-adrenal (HPA) axis, the central regulator of your body's stress response. Research suggests they interact with glucocorticoid receptors and influence GABAergic signaling, collectively contributing to anti-inflammatory, antioxidant, and anxiolytic actions. This HPA axis modulation is evident through lowered morning cortisol levels following supplementation.

The formula's additional adaptogens each contribute complementary mechanisms:

  • Bacopa leaf extract acts via antioxidant neuroprotection, acetylcholinesterase inhibition, and neurotransmitter modulation involving acetylcholine, serotonin, and dopamine — supporting memory, attention, and calm.
  • Rhodiola root extract works through dose-dependent HPA axis modulation, monoaminergic neurotransmitter effects (serotonin, dopamine, norepinephrine), and heat shock protein induction — supporting stress resilience and energy.
  • Schisandra fruit contains genus-specific lignans that suppress excess cortisol, enhance hepatic antioxidant enzymes, and support mitochondrial energy production — traditionally valued as a tonic across Chinese and Russian medicine.
  • Black pepper fruit extract contains piperine, which enhances the bioavailability of co-administered compounds by inhibiting CYP3A4, P-glycoprotein, and UDP-glucuronosyltransferase enzymes — helping your body absorb more of the formula's active ingredients.

Together, these ingredients are designed to help stabilize the long-term stress response, support cognitive performance, and promote physical endurance.

Qué contiene

Key ingredients

Ashwagandha root extract — 600 mg
Ashwagandha (Withania somnifera) is one of the most important herbs of Ayurveda, used for over 3,000 years as a Rasayana for wide-ranging health benefits. Its principal bioactive compounds are withanolides — steroidal lactones that modulate the HPA axis, reduce cortisol, and exhibit GABAergic activity. Multiple randomized controlled trials and meta-analyses demonstrate that Ashwagandha root extract significantly reduces anxiety and perceived stress scores. A 2024 meta-analysis of 9 RCTs (558 patients) showed significant reductions on the Hamilton Anxiety Scale and Perceived Stress Scale, while a 2025 meta-analysis of 15 RCTs (873 patients) corroborated significant cortisol reduction. Research also suggests Ashwagandha supports athletic performance: studies show VO2 max increases of 6–14% over 4–12 weeks, along with increased muscle mass, strength, and improved recovery. A systematic review found that 250–500 mg daily for 4 to 13 weeks significantly decreased morning cortisol levels in adults experiencing higher stress. Additionally, standardized Ashwagandha extracts have shown improvements in cognitive performance, including memory, executive function, sustained attention, and processing speed in adults with mild cognitive impairment. The extract also supports nervous system health through modulation of GABA, serotonin, brain-derived neurotrophic factor (BDNF), and NF-κB inflammatory pathways. Ashwagandha may also support endocrine balance: studies suggest it elevates thyroid hormone levels (T3, T4) in subclinical hypothyroidism and increases LH and FSH in men, supporting reproductive hormonal health.
Bacopa leaf extract — 395 mg
Bacopa monnieri, commonly known as Brahmi, is an Ayurvedic herb used for over 3,000 years as a medhya rasayana — a class of herbs traditionally believed to improve memory, intellect, and mental health. Its active compounds, the bacosides, act via antioxidant neuroprotection in the hippocampus and cortex, acetylcholinesterase inhibition to support cholinergic neurotransmission, and modulation of serotonin, dopamine, GABA, and acetylcholine. Multiple randomized controlled trials demonstrate that Bacopa may improve memory free recall, with a meta-analysis confirming potential to improve cognitive performance and speed of attention by reducing choice reaction time. In elderly adults without dementia, 300 mg/day for 12 weeks enhanced delayed word recall memory scores, providing evidence for safely enhancing cognitive performance in aging. Clinical studies also report reduced anxiety scores alongside cognitive improvements. Additionally, Bacopa modulates HPA axis activity: animal evidence shows bacosides reduce stress-induced corticosterone elevation, supporting its traditional role as a nervine tonic for stress resilience and calm.
Black pepper fruit extract — 395 mg
Black pepper (Piper nigrum L.), known as the "King of Spices," has been used in Ayurvedic medicine for thousands of years, where it forms part of the herbal preparation trikatu alongside long pepper and ginger. Its major bioactive compound, piperine, is one of the most clinically documented bioavailability enhancers available. Piperine inhibits CYP3A4, P-glycoprotein, and UDP-glucuronosyltransferase enzymes — the body's mechanisms for metabolizing and rapidly eliminating ingested compounds. In human pharmacokinetic studies, piperine increased curcumin bioavailability by approximately 2000%. This bioenhancing action means piperine may help your body absorb and retain more of the adaptogenic compounds in this formula. Black pepper is listed by the FDA as generally recognized as safe (GRAS) for its intended use as a spice and flavoring.
Schisandra fruit — 395 mg
Schisandra chinensis, known in Traditional Chinese Medicine as wu wei zi ("five-flavored fruit"), has a therapeutic history spanning thousands of years across Chinese, Korean, and Russian herbal traditions. It was first recorded in Shen Nong's Materia Medica in the first century BC as a Superior Herb. Schisandra's principal bioactives are dibenzocyclooctadiene lignans — including schisandrin, schisandrin B, and gomisin A — which exhibit antioxidant, hepatoprotective, and anti-inflammatory properties. Research suggests Schisandra supports stress resilience as a classified adaptogen: it was incorporated into official Soviet medical practice in the 1960s based on documented anti-fatigue and restorative effects. Studies show it modulates the HPA axis by suppressing excess cortisol release and prevents stress-induced increases in nitric oxide that can deplete ATP. Good scientific evidence has been documented for increased endurance and mental performance in patients with mild fatigue and weakness, receiving a grade B/C recommendation across 5 clinical trials. A randomized, double-blind, placebo-controlled trial in older adults found Schisandra extract significantly increased quadriceps muscle strength and decreased lactate levels, effects attributed to enhanced mitochondrial function and ATPase activity. In TCM, Schisandra is traditionally used to calm the spirit, benefit the five visceral organs, and support liver, lung, and kidney function.
Rhodiola root extract — 395 mg
Rhodiola rosea (golden root, arctic root) is a flowering perennial from Arctic regions of Europe and Asia, used medicinally since at least 77 AD when the Greek physician Dioscorides described its applications. Its key bioactive compounds — rosavins and salidroside — exert adaptogenic effects through dose-dependent HPA axis modulation, monoaminergic neurotransmitter regulation, and heat shock protein (HSP-70) induction. The European Medicines Agency (EMA) has approved Rhodiola for temporary relief of stress-related symptoms based on well-established traditional use and clinical evidence. Multiple RCTs demonstrate that Rhodiola extracts reduce stress-induced fatigue, burnout symptoms, and cortisol levels. A clinical trial of 101 adults taking 200 mg twice daily for four weeks showed significant improvements in stress, fatigue, mood, and quality of life. A separate trial in 118 burnout patients reported notable reductions in fatigue and burnout symptoms. Rhodiola also supports physical performance: in endurance testing, 100 mg of standardized extract significantly increased time to exhaustion, VO₂, and peak oxygen output in healthy volunteers. Research additionally suggests modest antidepressant effects: a proof-of-concept trial compared Rhodiola to sertraline for mild-to-moderate major depressive disorder and found fewer adverse events with Rhodiola, though it produced a less pronounced antidepressant effect.
Ashwagandha
Ashwagandha
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Ashwagandha
Ashwagandha
$40.95
Who Benefits

Who Is This Adaptogenic Ashwagandha Blend For?

This vegan formula is formulated for adults looking to address multiple dimensions of well-being through adaptogenic support:

  • People dealing with chronic or everyday stress: Research suggests the adaptogens in this blend — Ashwagandha, Rhodiola, Schisandra, and Bacopa — may help stabilize the long-term stress response and improve resistance toward stress and anxiety by modulating the HPA axis and lowering cortisol.
  • Active individuals and athletes: Studies suggest Ashwagandha supports physical performance, endurance, and wellness. VO2 max — a measure of the aerobic endurance representing the functional health of combined cardiovascular, pulmonary, and skeletal muscle systems — has been shown to increase by 6–14% in Ashwagandha studies. Rhodiola and Schisandra are traditionally used to decrease physical fatigue and support endurance.
  • Those seeking cognitive support: Bacopa is traditionally classified as a medhya rasayana for memory and intellect, while Ashwagandha has shown improvements in memory, executive function, and processing speed. This combination helps support cognitive performance in aging and helps sharpen the mind-body connection.
  • Adults seeking immune and nervous system support: The adaptogenic ingredients in this formula have traditionally been used to support both the immune and nervous systems.

Not sure whether this formula is appropriate for your situation? Our naturopath is available for a free consultation to discuss how adaptogenic herbs may fit into your wellness routine.

Directions

How to Take This Ashwagandha Blend

Take 2 VegCaps daily. Each serving of 2 VegCaps delivers the full complement of adaptogenic extracts in this formula. The product provides 60 VegCaps per bottle, which is a 30-day supply at the recommended serving size.

Important safety considerations: Ashwagandha should be avoided during pregnancy and should not be used while breastfeeding. It is not recommended for people who are about to have surgery, or for those who have autoimmune or thyroid disorders. Because Ashwagandha may increase testosterone levels, people with hormone-sensitive prostate cancer should avoid its use. There is evidence that Ashwagandha might interact with some medications, including those for diabetes and high blood pressure, immunosuppressants, sedatives, anticonvulsants, and thyroid hormone medications. Rhodiola, Schisandra, and Bacopa may also interact with certain medications through cytochrome P450 enzyme modulation.

If you take prescription medications or have a health condition, we encourage you to reach out to our naturopath for a free consultation before starting any new supplement.

Sobre el autor

Escrito por Greg Howlett

GH

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

Dudas comunes

Preguntas frecuentes

What is Ashwagandha used for?

Ashwagandha has been used in Ayurvedic medicine for over 3,000 years as a Rasayana — an herbal preparation that promotes physical and mental health. In this formula, Ashwagandha root extract is combined with Bacopa, Rhodiola, and Schisandra to support stress response, HPA axis balance, athletic performance, cognitive function, and immune and nervous system health.

How does Ashwagandha help with stress?

Research suggests Ashwagandha's active withanolides modulate the hypothalamic-pituitary-adrenal (HPA) axis and exhibit GABAergic activity, which may account for its anxiolytic effects. A 2025 meta-analysis of 15 RCTs (873 patients) found that Ashwagandha supplementation significantly reduced cortisol levels, perceived stress, and anxiety scores compared to placebo. This formula enhances that stress-supportive action with Rhodiola, Schisandra, and Bacopa — all recognized adaptogens with complementary mechanisms.

Can Ashwagandha support exercise and physical performance?

Studies suggest Ashwagandha extracts may increase VO2 max by 6–14% over 4–12 weeks, along with improvements in muscle mass, strength, and recovery. VO2 max is a measure of aerobic endurance representing the functional health of the cardiovascular, pulmonary, and skeletal muscle systems. Rhodiola and Schisandra in this formula offer additional exercise-related support: Rhodiola has shown increases in time to exhaustion in endurance testing, and Schisandra significantly increased quadriceps muscle strength in a placebo-controlled trial.

Is this Ashwagandha formula safe to take with medications?

Ashwagandha may interact with medications for diabetes, high blood pressure, thyroid conditions, immunosuppressants, sedatives, and anticonvulsants. Additionally, the other ingredients in this blend — Rhodiola, Schisandra, Bacopa, and Black pepper (piperine) — can influence cytochrome P450 enzyme activity and P-glycoprotein transport, potentially altering how your body metabolizes certain drugs. If you take any prescription medications, we strongly recommend speaking with a healthcare provider. Our naturopath is also available for a free consultation.

How long does it take for Ashwagandha to work?

Most clinical studies evaluating Ashwagandha for stress and anxiety used treatment periods of 30 to 90 days. For cognitive outcomes, studies with Bacopa typically observed effects after 12 weeks of consistent use. Athletic performance studies with Ashwagandha ranged from 4 to 12 weeks. Individual results may vary, and most of the existing research base involves study periods of 2 to 3 months.

Is this Ashwagandha formula vegan?

Yes. This formula is vegan-friendly and comes in VegCaps. The serving size is 2 VegCaps daily, providing 60 capsules per bottle for a 30-day supply.

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What Is Ashwagandha? Benefits, Ingredients & More