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What Is Vitamin C? Benefits, Sources & How It Works

Discover what Vitamin C is, why it matters for immune health and antioxidant defense, and how time-release supplementation supports your body throughout the day.

Essential Nutrient

What Is Vitamin C?

If you've ever wondered "what is Vitamin C," you're asking about one of the most essential and most studied nutrients in human biology. Vitamin C — also known as ascorbic acid — is a water-soluble vitamin that the body cannot produce on its own due to a genetic mutation in the L-gulonolactone oxidase (GLO) gene. That means every milligram must come from food or supplementation.

Vitamin C is a potent antioxidant and a cofactor for many enzymes involved in biological functions including immune system support, collagen biosynthesis, carnitine and catecholamine metabolism, and dietary iron absorption. It exists in two main forms: ascorbic acid (AA) and dehydroascorbic acid (DHA), with the L-enantiomer (L-ascorbic acid) being the biologically active form in humans.

The best dietary sources of Vitamin C are fruits and vegetables — especially citrus fruits, red and green peppers, kiwifruit, broccoli, and strawberries. Because Vitamin C is water-soluble and heat-sensitive, up to 50 percent can be lost through cooking, so eating produce raw or lightly steamed helps maximize intake.

Why It Matters

How Vitamin C Supports Your Body

Understanding what is Vitamin C really means understanding how deeply it is woven into your body's daily operations. As an antioxidant, Vitamin C scavenges reactive oxygen species (ROS) in aqueous environments and may regenerate other antioxidants such as vitamin E. Research suggests it helps diminish lipid peroxidation and reduce biomarkers of oxidative damage.

Vitamin C is also essential for collagen biosynthesis — the protein required for wound healing, skin integrity, and the structural framework of blood vessels, bones, and cartilage. Without adequate Vitamin C, prolyl and lysyl hydroxylase enzymes cannot properly hydroxylate collagen precursors, which is the biochemical basis of scurvy's connective tissue breakdown.

On the immune front, research shows Vitamin C contributes to both innate and adaptive immunity. It supports epithelial barrier function against pathogens, enhances phagocytosis, promotes the differentiation and proliferation of B cells and T cells, normalizes cytokine production, and decreases histamine levels. Plasma concentrations of Vitamin C decline rapidly during viral infections, underscoring its active role in immune defense.

Vitamin C also enhances iron absorption from plant-based foods by reducing ferric iron (Fe³⁺) to the more absorbable ferrous form (Fe²⁺) in the gastrointestinal tract — a clinically relevant function for anyone relying on non-heme iron sources.

If you have questions about how Vitamin C fits into your own wellness routine, our naturopath is available for a free consultation.

Research Highlights

What Does the Science Say About Vitamin C?

The scientific literature on Vitamin C is vast. Here are some of the key areas where evidence is strongest:

Common Cold

A Cochrane review of 30 placebo-controlled trials involving over 11,000 participants found that regular Vitamin C supplementation does not reduce common cold incidence in the general population. However, it may modestly reduce cold duration — by about 8% in adults and 14% in children — and severity. The benefit appears more pronounced in people under severe physical stress, such as marathon runners and military personnel.

Immune Function

More than half a century of research has shown Vitamin C to be a crucial player in immune cell function, including antimicrobial and natural killer cell activities, lymphocyte proliferation, and chemotaxis. Mechanistic evidence is well-established; however, human clinical evidence demonstrating that supplementation above adequate intake meaningfully improves immunity in non-deficient individuals is limited.

Antioxidant Defense

Multiple human trials demonstrate that Vitamin C supplementation raises antioxidant capacity and reduces biomarkers of oxidative damage, though clinical endpoints such as disease prevention show more mixed results. The evidence base is substantial, mechanistically well-characterized, and supported by peer-reviewed systematic reviews.

Age-Related Macular Degeneration (AMD)

The AREDS and AREDS2 studies demonstrated that a supplement formula including 500 mg Vitamin C alongside vitamin E, zinc, and copper may reduce progression to advanced AMD by 25% over five years in some patients. This is one of the few nutritional supplements with demonstrated benefit in eye disease, though the effect cannot be attributed to Vitamin C alone.

Time-Release Formula

About This Vitamin C Time Release Tablet

Nature's Sunshine Vitamin C Time Release is designed to deliver Vitamin C's benefits throughout the day. Each tablet includes a special coating that slows absorption until the nutrients reach the intestines — an important design feature because intestinal absorption of ascorbic acid is dose-dependent, and absorption falls to about 50 percent or less at doses above 1 g/day. By releasing the nutrient gradually, a time-release format may help the body utilize more of each serving.

This formula blends ascorbic acid with a base of Rose hips extract, acerola extract, Rutin, Lemon bioflavonoids, and Hesperidin complex — a completely natural product with no sugar, starch, artificial colorings, or flavorings. It is also vegan and non-GMO.

The product highlights include supporting the immune system, fighting free radicals, nourishing the tissues, and assisting in the production of collagen.

Ideal Users

Who May Benefit from Vitamin C Supplementation?

Because the body cannot make or store Vitamin C, virtually everyone needs a steady daily supply. This product may be especially relevant for:

  • Anyone seeking immune support — Vitamin C's role in immune cell function is one of the most well-documented in nutritional science.
  • People looking for antioxidant defense — especially those concerned about environmental oxidative stress or wanting to support skin health through collagen synthesis.
  • Individuals who eat limited fresh fruits and vegetables — cooking, freezing, and processing significantly reduce Vitamin C content in food.
  • Those under physical stress — research suggests the benefits of regular Vitamin C supplementation on cold duration are more pronounced in people exposed to severe physical exertion.
  • People who want plant-based support — this vegan, non-GMO formula is built on a base of whole-food extracts including Rose hips and acerola.

The RDA for Vitamin C is 90 mg/day for adult men and 75 mg/day for adult women, with smokers recommended to add 35 mg/day. The Tolerable Upper Intake Level (UL) is set at 2,000 mg/day for adults.

What's inside

Key ingredients

Vitamin C (ascorbic acid) — 10000 mg
Vitamin C (ascorbic acid) is the primary bioactive ingredient in this formula. As a water-soluble antioxidant, it directly scavenges reactive oxygen species in aqueous cellular compartments and plasma, and research suggests it may regenerate the antioxidant form of vitamin E at membrane interfaces. Multiple human trials demonstrate that supplementation raises antioxidant capacity and reduces biomarkers of oxidative damage. Vitamin C is essential for collagen biosynthesis — acting as a cofactor for prolyl and lysyl hydroxylase enzymes — and supports skin integrity, wound repair, and connective tissue health. It contributes to immune defense by supporting epithelial barrier function, enhancing phagocytosis, promoting B-cell and T-cell differentiation, normalizing cytokine production, and decreasing histamine levels. A Cochrane review of 29 trials (over 11,000 participants) found that regular supplementation modestly reduces cold duration by about 8% in adults and 14% in children, with more pronounced benefits in people under severe physical stress. Studies also suggest Vitamin C supports bronchial health, with supplementation at ≥400 mg/day shown to improve FEV1% in patients with chronic obstructive pulmonary disease. Additionally, Vitamin C enhances iron absorption from plant-based foods and participates in carnitine synthesis, neurotransmitter production, and adrenal steroid metabolism.
Rose hips — 25 mg
Rose hips are the pseudo fruits of Rosa canina L. and have been used in herbal medicine for more than 2,000 years. They are among the richest natural plant sources of Vitamin C, with content reported as high as 1,300 mg/100 g depending on variety and processing. Beyond Vitamin C, Rose hips contain polyphenols, carotenoids (lycopene, beta-carotene), tocopherols, flavonoids, and a galactolipid known as GOPO that has demonstrated anti-inflammatory properties. Rose hip extract ranks among the highest measured antioxidant activities in tested fruits by ORAC, TRAP, and HORAC assays, and clinical studies suggest increased antioxidant status in healthy adults following supplementation. Research suggests the Vitamin C in Rose hips supports immune defense and may help reduce the duration and severity of common cold symptoms — meta-analyses of Vitamin C supplementation show an 8–14% reduction in cold duration. Historically, rose hip has been used as a febrifuge in European folk medicine and as a recovery tonic after illness, attributed to its broad antioxidant and immune-supportive profile. Rose hip tea and syrup were traditionally consumed for colds, coughs, and upper respiratory complaints across European and Scandinavian herbal traditions.
acerola fruit extract — 25 mg
Acerola (listed here as acerola fruit extract) is a concentrated source of anthocyanins and polyphenolic compounds with documented antioxidant activity. Research suggests tart Cherry anthocyanins upregulate endogenous antioxidant pathways, including Nrf2/ARE, and human randomized controlled trials show increased DNA repair enzyme (OGG1) activity and reduced oxidative stress markers such as MDA and oxidized LDL following supplementation. Studies also suggest its anthocyanins modulate immune-inflammatory signaling by inhibiting COX-1/2 and NF-κB, reducing TNF-α, IL-1β, and IL-6 in human studies, reflecting immune system modulation. These antioxidant and immune-supportive properties complement the Vitamin C in this formula.
Rutin — 25 mg
Rutin (quercetin-3-O-rutinoside) is a flavonoid glycoside found naturally in buckwheat, citrus fruits, and many other plants. It was historically known as "vitamin P" after being first separated from a flavonoid mixture in the 1930s. Rutin is a documented antioxidant that works through multiple mechanisms: direct free-radical scavenging, upregulation of endogenous antioxidant enzymes (SOD, catalase, glutathione peroxidase), and activation of the Nrf2/ARE pathway. Preclinical evidence consistently shows reductions in oxidative stress biomarkers. Rutin is also particularly recognized for its beneficial effects on vascular health — research suggests it strengthens capillary walls, reduces their permeability and fragility, and helps prevent edema. Studies show that Rutin modulates multiple arms of immunity: it suppresses pro-inflammatory cytokine production, inhibits mast cell activation, and exerts NF-κB-dependent immunomodulatory effects. In this formula, Rutin complements Vitamin C's antioxidant and immune-supportive actions.
Hesperidin bioflavonoid extract — 25 mg
Hesperidin is a flavanone glycoside naturally abundant in citrus fruits, first isolated in 1828 from the inner layer of citrus peels. Its biological activity is largely attributed to its aglycone form, hesperetin, which is released after gut microbial hydrolysis. Research suggests Hesperidin is a potent natural antioxidant that scavenges reactive oxygen species, enhances endogenous antioxidant enzyme activity (SOD, catalase, glutathione), and activates the ERK/Nrf2 signaling pathway — effects demonstrated in vitro, in animal studies, and in human trials measuring oxidative stress biomarkers. Hesperidin also modulates the immune system by downregulating pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and upregulating anti-inflammatory IL-10, inhibiting NF-κB. A human randomized controlled trial showed a Hesperidin-containing supplement improved immune function and enhanced the oxidative-inflammatory state in adults. Additionally, Hesperidin exhibits anti-allergic properties by inhibiting mast cell degranulation and suppressing histamine release, and preclinical studies suggest protective effects against airway inflammation.
Lemon bioflavonoid extract — 25 mg
Lemon bioflavonoid extract is derived from Citrus × limon and provides a complex of citrus flavonoids — including Hesperidin, eriocitrin, and diosmin — along with naturally occurring Vitamin C. Lemon is a well-characterized source of flavonoids with documented antioxidant capacity; a double-blind randomized controlled trial found that citrus extract combined with Vitamin C significantly increased lipoprotein oxidation lag time, outperforming vitamin E as an antioxidant. The Vitamin C content in Lemon supports immune defense against respiratory infections — a Swiss clinical review found Vitamin C intake improved symptoms and shortened duration of respiratory tract infections. Lemon's principal flavonoid, Hesperidin, has computational and in vitro evidence of binding viral proteins, while its Vitamin C supports natural killer cell activity, lymphocyte function, and interferon production relevant to viral clearance. Traditionally, Lemon has been used across cultures for fever management and sore throat relief.
dicalcium phosphate
Dicalcium phosphate is a Calcium salt used as a tablet base in this formula. Calcium is the most abundant mineral in the human body, with more than 99% stored in bone as hydroxyapatite. Beyond its structural role in the skeleton, Calcium is essential for muscle contraction, neuronal transmission, hormone secretion, and cellular signaling. It participates in the mineralization of calcified tissues and its homeostasis is tightly regulated by parathyroid hormone, calcitonin, and vitamin D.
Vitamin C (1000 mg, Time Release)
Vitamin C (1000 mg, Time Release)
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Vitamin C (1000 mg, Time Release)
Vitamin C (1000 mg, Time Release)
$47.65
Directions

How to Take This Vitamin C Supplement

Take one tablet daily with a meal.

The time-release coating is designed to slow absorption until the nutrients reach the intestines, helping your body utilize Vitamin C gradually throughout the day rather than in a single burst.

About the author

Written by Greg Howlett

GH

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What is Vitamin C and why can't the body make it?

Vitamin C (ascorbic acid) is a water-soluble nutrient that functions as a potent antioxidant and an essential cofactor for many enzymes. The human body cannot synthesize Vitamin C due to mutations in the L-gulonolactone oxidase (GLO) gene, which is responsible for its synthesis from L-gulono-1,4-lactones. This means you must obtain Vitamin C from food or supplementation every day.

Does Vitamin C prevent the common cold?

Research suggests that for most people, regular Vitamin C supplementation does not reduce the risk of getting a cold. However, a Cochrane review of 29 trials involving over 11,000 participants found that regular supplementation may modestly reduce cold duration — by about 8% in adults and 14% in children — and somewhat reduce severity. People under severe physical stress, such as marathon runners, may see a greater preventive benefit. Taking Vitamin C after a cold has already started does not appear to be helpful.

What is a time-release Vitamin C tablet?

A time-release tablet features a special coating that slows nutrient absorption until it reaches the intestines, releasing Vitamin C gradually throughout the day. This is relevant because intestinal absorption of ascorbic acid is dose-dependent — at doses above 1 g/day, absorption can fall to about 50% or less. A time-release delivery may help the body utilize more of the Vitamin C in each serving.

How much Vitamin C do I need daily?

The Recommended Dietary Allowance (RDA) is 90 mg/day for adult men and 75 mg/day for adult women. Pregnant and lactating women are advised to increase intake to 85 mg and 120 mg per day, respectively. Smokers are recommended to consume an additional 35 mg/day regardless of sex. The Tolerable Upper Intake Level (UL) for adults is set at 2,000 mg/day to prevent gastrointestinal side effects.

Are there any safety concerns with Vitamin C supplementation?

When taken at suggested doses, Vitamin C supplements are mostly safe. At amounts greater than 2,000 mg/day, side effects including stomach upset, diarrhea, and stomach cramps may occur. There is some evidence that high-dose Vitamin C may increase kidney stone risk, particularly in people with existing risk factors. People with G6PD deficiency, hemochromatosis, or those on anticoagulant medications should consult a healthcare professional before supplementing. High doses are not recommended during pregnancy.

What makes this formula different from plain Vitamin C tablets?

This Nature's Sunshine formula blends ascorbic acid with a base of Rose hips extract, acerola extract, Rutin, Lemon bioflavonoids, and Hesperidin complex — naturally occurring plant compounds that provide complementary antioxidant and immune-supportive benefits. The time-release coating is designed to deliver these nutrients gradually, and the product is completely natural with no sugar, starch, artificial colorings, or flavorings. It is also vegan and non-GMO.

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