Evidence supporting the use of: Valine alpha-hydroxyisocaproate
For the health condition: Athletic and Exercise Aids
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Valine alpha-hydroxyisocaproate (also known as HICA or leucic acid) is a metabolite of the branched-chain amino acid leucine. It has been marketed as a supplement for athletes, often with claims that it may support muscle growth, reduce muscle breakdown, and improve recovery after exercise. The rationale behind its use comes from both its biochemical relationship to leucine—which is well known for its role in muscle protein synthesis—and some preliminary scientific studies.
The scientific evidence supporting HICA's effectiveness as an athletic and exercise aid is limited but does exist. A few small, randomized controlled trials have explored its effects. For example, a 2010 study by Mero et al. found that male soccer players supplementing with HICA for four weeks experienced less muscle soreness and slightly greater increases in muscle mass compared to placebo. However, the sample sizes were small, and the findings have not been widely replicated. Some other studies have shown modest reductions in delayed-onset muscle soreness (DOMS) or markers of muscle damage.
No significant safety concerns have been noted in short-term studies, but longer-term data are lacking. Overall, while there is a scientific basis for the use of Valine alpha-hydroxyisocaproate as an exercise aid, the overall quality and quantity of evidence are low, and more research is needed to confirm its efficacy and optimal dosing. Therefore, its use is considered "scientific" but the strength of evidence is modest.
More about Valine alpha-hydroxyisocaproate
More about Athletic and Exercise Aids
Other ingredients used for Athletic and Exercise Aids
7-Keto-DHEAAcetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
Alpha D-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
bacillus subtilis
beet
beta-alanine
black tea
bovine
branched-chain amino acids
caffeine
capsaicinoids
coenzyme Q10 (CoQ10)
collagen
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
curcumin
eleuthero
ginseng
green tea
guarana
guayusa
l-isoleucine
L-alanine
L-alanyl-L-glutamine
L-arginine
l-carnitine
L-citrulline
L-glutamine
L-glycine
L-leucine
L-ornithine
L-taurine
l-tyrosine
L-valine
maca
magnesium
maltodextrin
Muira puama
Acetyl-L-Tyrosine
omega-3 fatty acids
ornithine alpha-ketoglutarate
Peppermint
protein
pyridoxal-5-phosphate (P-5-P)
Rhodiola
black ginger
spirulina
Tongkat ali
tribulus
vitamin C
Watermelon
Whey protein
suma
jiaogulan
capsicum
bee pollen
cistanche
electrolytes blend (proprietary)
Yerba mate
Algae
cocoa
brown rice protein
sea salt
1,3,7-Trimethylpurine-2,6-dione
arginine alpha ketoglutarate
antler
arginine creatine
Arginine nitrate
arachidonic acid
Arginine malate
Arginine aspartate
Alpha glyceryl
Alpha-ketoisocaproic acid
Agmatine
Adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine silicate
bicarbonate
Beef Protein
bovine protein
Bulbine natalensis
ba ji tian
BCAA
Camellia sinensis
coconut
casein
cardarine
capsinoids
citrate malate
capsiate
creatine
D-Aspartic Acid
dihydrocapsiate
deer velvet
D-Ribose
Ephedra
eurycomanone
elk antler
Eurycoma Longifolia
ecdysteroids
Ethyl-Alpha-Guanido-Methyl-Ethanoate
ecdysterone
ephedrine
Fadogia agrestis
guanidinoacetic acid
Ginsenosides
Glutamine
Growth factors
GMS-ribose
glucose
Glycocyamine
Guaranine
Glycerol
Higenamine
hydroxymethylbutyrate
HMB hydroxymethylbutyrate
horny goat weed
isomaltulose
Isoleucine
kola nut
ketone salts
lactalbumin
Laxogenin
macamides
maral root
Mineral ascorbate
Milk Protein
Methylxanthine
Methylliberine
Mate
Mushroom
macaenes
Nitrous Malate (TM) Diarginine Malate
Ornithine
Phosphocreatine
pyrroloquinoline quinone
paraxanthine
Phytoecdysteroid
pyruvate
Phosphatidic Acid
Piper nigrum
Palatinose
Peptides
Quinoa Protein
Rhaponticum
ribose
robusta coffee
Synephrine
Safed musli
salt
Sida cordifolia
Theobromine
Tripeptide
Trichilia catigua
Turkesterone
Trichopus zeylanicus
Theacrine
Teacrine
Tribulus Terrestris
Valine alpha-hydroxyisocaproate
Xanthine
Yohimbine
