Other names for Histidine alpha-ketoglutaric acid

histidine akg
l-histidine-alpha-ketoglutaric acid

Synopsis of Histidine alpha-ketoglutaric acid

History

Histidine alpha-ketoglutaric acid is a compound that combines the amino acid histidine with alpha-ketoglutaric acid, a key intermediate in the Krebs cycle. Historically, its components have been utilized individually in both traditional and modern medicinal remedies, celebrated for supporting metabolic and overall health. Histidine, found in various foods and herbal remedies, is known for its role in tissue repair, growth, and immune system modulation. It has been used to help manage conditions like rheumatoid arthritis, allergies, and ulcers, owing to its anti-inflammatory and antioxidant properties.

Alpha-ketoglutaric acid, meanwhile, has a legacy in clinical nutrition for its ability to support energy production and protein synthesis. It has been used in combination with other amino acids to improve recovery in surgical and critical care patients. Its role in detoxification and reducing ammonia levels in the body has made it a valued component in traditional European and Asian herbal preparations, particularly those targeting liver and kidney health.

When combined as histidine alpha-ketoglutaric acid, the synergy of these two ingredients offers enhanced support for cellular energy, detoxification, and immune function. In herbal combinations, this compound is often included with adaptogenic herbs such as ginseng, schisandra, or ashwagandha to optimize stamina, resilience, and metabolic balance. The positive contributions of histidine alpha-ketoglutaric acid to nutritional science are vast, and its historical application in various remedies underscores its enduring value in promoting vitality and well-being.

Traditional and scientific validation

Histidine alpha-ketoglutaric acid, sometimes referred to as a chelated or compound form of the amino acid histidine with alpha-ketoglutaric acid (AKG), has attracted attention in the field of nutrition for its potential benefits in metabolic health, athletic performance, and overall well-being. Histidine is an essential amino acid involved in protein synthesis, buffering, and as a precursor for important biomolecules such as histamine. Alpha-ketoglutaric acid is a key intermediate in the Krebs cycle, central to cellular energy production and amino acid metabolism.

Historically, both components have been individually studied for their positive effects. Histidine supplementation has been shown to support immune function and antioxidant status, while alpha-ketoglutaric acid has demonstrated benefits in preserving muscle mass, supporting gut health, and improving nitrogen balance, particularly in catabolic states or during intense physical activity.

The use of histidine alpha-ketoglutaric acid as a combined ingredient in nutritional products is based on the hypothesis that the pairing may enhance absorption and synergistically support metabolic pathways. While direct clinical studies on the specific compound are limited, preliminary research and anecdotal reports suggest that it may contribute to improved recovery, athletic performance, and metabolic support. Some studies on related chelated amino acid complexes indicate improved bioavailability and potential for better physiological effects compared to non-chelated forms.

Nevertheless, more rigorous scientific studies are needed to fully establish the efficacy and safety profile of histidine alpha-ketoglutaric acid in nutrition. Current evidence is promising, and ongoing research may further elucidate its benefits, making it a positive and intriguing option for inclusion in modern nutritional formulations.

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Products containing Histidine alpha-ketoglutaric acid

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