Organic Magnesium Complex | Heart, Brain & Kidney Support

An organic Magnesium Complex combines two or more highly bioavailable, organic forms of Magnesium — meaning the mineral is chelated to organic molecules like citric acid or malic acid rather than bound to inorganic salts. Nature's Sunshine Magnesium Complex pairs Magnesium citrate and Magnesium malate, both classified as organic Magnesium salts that are generally more soluble and have higher bioavailability than inorganic forms like Magnesium oxide.

Magnesium itself is the fourth most abundant cation in the human body and a critical cofactor in more than 300 enzyme systems that regulate energy metabolism, neuromuscular function, cardiovascular health, bone integrity, and more. Despite its importance, an estimated 56–68% of Americans do not obtain enough Magnesium in their daily diet to meet the recommended daily allowance.

This organic Magnesium Complex is designed to support the cardiovascular system, brain and nervous system function, and kidney health — delivering 184 mg of Magnesium per two-capsule serving in highly soluble forms your body can readily absorb.

Not all Magnesium supplements are created equal. Magnesium supplements are broadly categorized into organic and inorganic compounds. Organic forms — such as citrate and malate — involve Magnesium chelated to organic acid molecules. These forms are generally more soluble and have higher bioavailability compared to inorganic forms like Magnesium oxide, which was found to be virtually insoluble in water and only 43% soluble even in simulated peak acid secretion.

Magnesium citrate, one of the two forms in this organic Magnesium Complex, is recognized as one of the most bioavailable options. Research has shown that Magnesium citrate has high solubility even in water (55%) and was substantially more soluble than Magnesium oxide across all states of acid secretion. By pairing citrate with malate — another well-absorbed organic form — this formula offers optimum effectiveness through complementary absorption pathways.

The high solubility of these organic forms means more of the Magnesium you take actually reaches your bloodstream, where it can go to work supporting your heart, brain, kidneys, and the hundreds of enzymatic reactions that depend on this essential mineral.

Cardiovascular System

Research suggests Magnesium plays a well-documented role in cardiovascular health. Higher dietary and circulating Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and total cardiovascular disease across multiple large meta-analyses and prospective cohort studies. Magnesium regulates cardiac ion channels, vascular tone, and endothelial function, and studies suggest that supplementation may produce modest but significant reductions in blood pressure, particularly in Magnesium-deficient or hypertensive individuals.

Magnesium is also a well-established cofactor in cardiac electrophysiology, modulating ion channel exchanges and action potentials. A meta-analysis of 22 studies found that Magnesium significantly reduced both ventricular and supraventricular arrhythmias compared to placebo. Additionally, a 24-week randomized controlled trial found that 350 mg/day of Magnesium citrate significantly reduced arterial stiffness as measured by pulse wave velocity.

Nervous System and Brain Function

Magnesium is fundamental to nervous system function, acting as a physiological NMDA receptor antagonist and regulator of neuronal excitability, neuromuscular transmission, and nerve signaling. Deficiency is clinically associated with neuromuscular hyperexcitability, tremors, and seizures, and has been linked to neurological conditions ranging from migraine to depression.

Research also suggests Magnesium serves as an essential cofactor in dopamine synthesis (via tyrosine hydroxylase) and a blocker of NMDA glutamate receptor channels, supporting the balance between inhibitory and excitatory neurotransmitter activity. A 2017 RCT showed that 248 mg/day of Magnesium significantly reduced both depression and anxiety scores. Clinical evidence also supports Magnesium supplementation for nerve excitability modulation and neuropathic pain reduction.

Kidney Health

The kidneys are the primary site of Magnesium excretion and the major regulator of whole-body Magnesium homeostasis, with typically only 3–5% of filtered Magnesium excreted in urine. Research suggests that Magnesium is a well-established inhibitor of calcium oxalate crystallization in urine. A landmark double-blind RCT (n=64, up to 3 years) showed that new kidney stones formed in only 12.9% of treated subjects versus 63.6% on placebo. Magnesium supplementation may also help reduce urinary oxalate excretion and raise urinary citrate — both key protective factors against stone formation.

Because Magnesium is involved in over 300 enzymatic reactions and an estimated 56–68% of Americans fall short of the recommended daily allowance, a broad range of adults may benefit from supplementation. This organic Magnesium Complex may be especially relevant for:

• Adults concerned about heart health — Research suggests adequate Magnesium supports healthy blood pressure, arterial flexibility, and normal heart rhythm.
• Those focused on nervous system support — Magnesium acts as a natural NMDA receptor antagonist, modulating neuronal excitability and supporting neurotransmitter balance.
• People interested in kidney health — Studies suggest Magnesium may help inhibit calcium oxalate crystallization and support healthy urinary mineral balance.
• Older adults — Magnesium absorption and retention can decrease with age, and older individuals are more susceptible to deficiency due to decreased absorption from food, increased medication use, and potential dietary restrictions.
• Individuals on certain medications — Loop and thiazide diuretics, proton pump inhibitors, and other common medications can deplete Magnesium through increased urinary excretion or reduced absorption.

If you're unsure whether a Magnesium supplement is right for you, our naturopath is available for a free consultation to help you evaluate your individual needs.

Take 2 capsules twice daily with a meal. Each bottle contains 100 capsules.

It is important to be aware that Magnesium may interact with certain medications. Magnesium can form insoluble complexes with tetracycline and quinolone antibiotics — if you take these, separate them by at least 2 hours before or 4–6 hours after Magnesium. Magnesium-rich supplements should also be separated from oral bisphosphonates by at least 2 hours. Magnesium may reduce the absorption of gabapentin by approximately 20%.

If you take diuretics, proton pump inhibitors, or other medications, it is worth discussing Magnesium supplementation with your healthcare provider. Our naturopath is also happy to answer questions during a free consultation.