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NOW Foods Turmeric Curcumin Phytosome | Deep-Dive Guide

Explore our deep-dive guide on NOW Foods Turmeric Curcumin Phytosome — key ingredients, benefits for joints, inflammation, and antioxidant defense, plus how to take it.

Overview

What Is NOW Foods Turmeric Curcumin Phytosome and Why Does It Matter?

If you're looking for targeted support for joints, a healthy inflammatory response, and antioxidant defense, a well-formulated Turmeric Curcumin supplement can be a meaningful addition to your daily routine. Nature's Sunshine Turmeric Curcumin (Formerly CurcuminBP) harnesses Turmeric extract to promote a healthy inflammatory response, which in turn supports joint, skin, brain, and gut health as well as immune system function.

One serving of this formula is equivalent to 32,000 mg of whole root Turmeric. Rather than simply delivering high amounts of Turmeric root with minimal extract, this product provides both Turmeric root and higher levels of antioxidant-rich Turmeric extract — delivering 1,000 mg of curcuminoids per serving. It is also enhanced with Black pepper extract to improve absorption.

Curcumin, the primary active compound in Turmeric, has been safely used for centuries in Indian Ayurvedic medicine. Research suggests it supports a healthy inflammatory response through multiple molecular pathways, including NF-κB, COX-2, and JAK/STAT signaling. However, a central challenge with Curcumin is its inherently poor oral bioavailability — it is poorly absorbed, rapidly metabolized, and quickly eliminated. That's why the inclusion of Black pepper extract in this formula is so important: studies suggest piperine from Black pepper can significantly enhance Curcumin absorption.

If you have questions about whether a now foods Turmeric Curcumin phytosome supplement is right for your wellness goals, our naturopath is available for a free consultation to help you decide.

What's inside

Key Ingredients

Tumeric Extract — 1,100 mg
Turmeric (Curcuma longa L.) is a rhizomatous herbaceous perennial belonging to the ginger family, with a history of use spanning nearly 6,000 years in Ayurvedic and traditional Chinese medicine. The extract is standardized for curcuminoids — polyphenolic pigments responsible for Turmeric's vibrant yellow color — with Curcumin (diferuloylmethane) as the dominant active compound. Research suggests Curcumin supports a healthy inflammatory response by inhibiting NF-κB, COX-2, and LOX enzyme activity, reducing the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Multiple systematic reviews and meta-analyses of randomized controlled trials demonstrate that Turmeric extract supports joint comfort, stiffness reduction, and physical function in osteoarthritis, with some studies finding effects comparable to NSAIDs. Beyond joints, clinical studies suggest Curcumin may promote antioxidant defense by raising total antioxidant capacity (TAC), superoxide dismutase (SOD), and glutathione while lowering the lipid-peroxidation marker malondialdehyde (MDA) — primarily through activation of the Keap1-Nrf2/ARE pathway. A 2022 meta-analysis of 29 RCTs confirmed Curcumin's efficacy across five types of arthritis. Research also suggests benefits for cartilage health: a landmark comparative RCT (n=367 knee OA patients) found Turmeric extract equivalent to ibuprofen 1,200 mg/day for knee pain relief, and ESCEO guidelines recognize curcuminoids as an OA nutraceutical. Preliminary evidence supports potential benefits for flexibility and mobility, with a 2025 network meta-analysis ranking Curcumin among the most effective supplements for joint function outcomes. Historically, Turmeric has been used in Ayurvedic medicine for digestive disorders, skin conditions, and inflammatory ailments. It is important to note that Curcumin's poor oral bioavailability remains a central limitation, which is why this formula includes Black pepper extract to help address that challenge.
Curcuminoids — 1,000 mg
Curcuminoids are the family of phenolic pigments found in Turmeric, comprising Curcumin (approximately 77%), demethoxycurcumin (approximately 17%), and bisdemethoxycurcumin (approximately 3%). Curcumin, the most potent of the naturally occurring curcuminoids, was first discovered from the Turmeric rhizome in 1815. Research suggests curcuminoids exert anti-inflammatory effects by inhibiting NF-κB, MAPK, JAK/STAT, and NLRP3 inflammasome pathways, while activating the Nrf2 antioxidant pathway. Multiple meta-analyses of RCTs demonstrate that curcuminoids significantly reduce inflammatory biomarkers — CRP, IL-6, and TNF-α — in supplemented individuals. For joint health, a meta-analysis of 29 RCTs (2,396 participants across five arthritis types) confirmed significant reductions in pain and inflammation, while a 2014 head-to-head RCT found 1,500 mg/day Curcumin equivalent to ibuprofen 1,200 mg/day in knee OA. A 2025 systematic review of 21 studies (1,705 patients) found that CRP and TNF-alpha levels were significantly lower in Curcumin groups versus placebo in knee OA specifically. Research also suggests curcuminoids support antioxidant defense: clinical evidence shows they significantly reduce malondialdehyde (MDA) and raise enzymatic antioxidants including SOD, catalase, and glutathione peroxidase. For cartilage health, Curcumin inhibits inflammatory cytokines (IL-1β, TNF-α, MMPs) that drive cartilage degradation, with a 2021 meta-analysis of 10 RCTs confirming significant reductions in WOMAC pain and stiffness. Curcumin has also been studied for rheumatoid arthritis, with a 2025 network meta-analysis of 18 RCTs finding it superior to placebo for reducing swollen and tender joint counts. Poor oral bioavailability remains a key limitation, which is why enhanced delivery strategies — such as co-administration with piperine — are used to improve absorption.
Black pepper Extract
Black pepper (Piper nigrum L.), often called the "King of Spices," contains piperine as its major bioactive alkaloid. In the context of this formula, Black pepper extract serves a critical role: it significantly enhances the absorption of Curcumin. In a landmark human study, co-administering 20 mg of piperine with Curcumin increased Curcumin's blood concentrations by 2,000% within 45 minutes. The mechanism involves piperine's inhibition of UDP-glucuronosyltransferase (UGT) enzymes and CYP3A4, which slows the metabolic breakdown and excretion of Curcumin. Research also suggests piperine possesses its own anti-inflammatory properties: it inhibits COX-2 gene expression and enzyme activity, suppressing prostaglandin E2 (PGE2) generation. In vitro studies using human rheumatoid arthritis synoviocytes found piperine inhibited IL-6, MMP13, COX-2, and PGE2 in a dose-dependent manner. Piperine also demonstrates antioxidant activity — human RCTs using Curcumin-piperine combinations show improvements in superoxide dismutase, total antioxidant capacity, and malondialdehyde in metabolic syndrome populations. In Ayurveda, Black pepper is one of the three ingredients in <em>trikatu</em>, a classical herbal preparation, and approximately two-thirds of all traditional Ayurvedic formulations include Black pepper for its bioenhancing properties. Black pepper is listed by the FDA as generally recognized as safe (GRAS). Important note: piperine's inhibition of CYP3A4 and P-glycoprotein means it may alter the metabolism of co-administered medications — individuals taking prescription drugs should consult a healthcare practitioner.
Dicalcium Phosphate
Dicalcium phosphate is a Calcium compound commonly used as an excipient in supplement formulations, where it serves as a tableting or capsule-filling agent. Calcium is the most abundant mineral in the human body, with more than 99% stored in bones and teeth as hydroxyapatite. It plays essential roles in muscle contraction, nerve signal transmission, and cellular signaling. In this formula, dicalcium phosphate functions primarily as a structural component of the capsule rather than as a primary active ingredient.
Turmeric Curcumin (Formerly CurcuminBP)
Turmeric Curcumin (Formerly CurcuminBP)
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Turmeric Curcumin (Formerly CurcuminBP)
Turmeric Curcumin (Formerly CurcuminBP)
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Ideal Users

Who Is NOW Foods Turmeric Curcumin Phytosome For?

This formula is designed for adults looking for natural support in several key areas. If you experience occasional joint stiffness or discomfort, research suggests curcuminoids may help promote joint comfort and physical function. Multiple systematic reviews have found benefits across several types of arthritis, including osteoarthritis and rheumatoid arthritis.

If you're focused on supporting a healthy inflammatory response, this supplement delivers 1,000 mg of curcuminoids per serving — the primary compounds studied for their ability to modulate NF-κB and COX-2 inflammatory pathways. Research suggests Curcumin may help lower inflammatory biomarkers like CRP, IL-6, and TNF-α.

Those interested in antioxidant defense may also benefit: clinical studies suggest Curcumin raises total antioxidant capacity and supports endogenous antioxidant enzymes while reducing markers of oxidative stress.

This product is also non-GMO and comes in VegCaps, making it suitable for individuals who prefer plant-based capsule formats. If you're unsure whether this formula aligns with your health goals, our naturopath offers free consultations — no membership or appointment fees required.

Usage

How to Take NOW Foods Turmeric Curcumin Phytosome

Take 2 VegCaps daily. Each serving (2 capsules) delivers 1,100 mg of tumeric extract providing 1,000 mg of curcuminoids, along with Black pepper extract to support absorption.

The inclusion of Black pepper extract is particularly important because Curcumin has inherently poor oral bioavailability. Studies have shown that piperine from Black pepper can dramatically increase Curcumin absorption, helping your body make better use of each serving.

As with any supplement, it's a good idea to speak with a healthcare professional before starting — especially if you are taking prescription medications. Piperine's inhibition of certain metabolic enzymes (CYP3A4, P-glycoprotein) may alter how some drugs are processed. If you'd like personalized guidance, our naturopath is happy to help through a free consultation.

The Science

What the Research Says About Turmeric Curcumin

The body of clinical evidence behind Turmeric and Curcumin continues to grow, particularly for joint health and inflammatory response. A 2025 systematic review and network meta-analysis of 17 studies found that all Turmeric preparations significantly reduced WOMAC pain scores in knee osteoarthritis, with bioavailability-enhanced formulations demonstrating a 30% reduction in WOMAC pain compared to placebo — reaching the minimum clinically important difference threshold.

A 2022 systematic review in Frontiers in Immunology examined 29 RCTs involving 2,396 participants across five types of arthritis and verified that Curcumin had treatment efficacy similar to NSAIDs based on findings from 16 RCTs and 1,810 adults. However, the evidence quality is consistently rated low to very low due to small sample sizes, high risk of bias, and heterogeneity across formulations and doses.

For antioxidant defense, multiple human RCTs and meta-analyses show Curcumin measurably raises total antioxidant capacity (TAC), SOD, catalase, and glutathione while lowering malondialdehyde (MDA). The primary mechanism involves activation of the Keap1-Nrf2/ARE transcriptional pathway.

Research into metabolic health is also promising. A 2025 meta-analysis found Curcumin supplementation significantly reduced fasting blood sugar, HbA1c, triglycerides, and LDL cholesterol while raising HDL cholesterol and total antioxidant capacity in individuals with metabolic syndrome and type 2 diabetes. However, heterogeneity was moderate-to-high across these studies.

It's worth noting that Curcumin's clinical application faces a significant bottleneck: its poor oral bioavailability. Numerous factors — low water solubility, poor intestinal permeability, instability at alkaline pH, and rapid metabolism — all contribute. This is precisely why the Black pepper extract in this formula matters: the piperine it contains has been shown to increase Curcumin bioavailability by up to 2,000% in human studies.

About the author

Written by Greg Howlett

GH

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What makes this Turmeric Curcumin formula different from standard Turmeric supplements?

This formula delivers both Turmeric root and higher levels of antioxidant-rich Turmeric extract, providing 1,000 mg of curcuminoids per serving — equivalent to 32,000 mg of whole root Turmeric. It also includes Black pepper extract, which studies have shown can increase Curcumin absorption by up to 2,000%. Many standard Turmeric supplements provide high amounts of Turmeric root with relatively little concentrated extract.

Why is Black pepper extract included in a Turmeric Curcumin supplement?

Curcumin has inherently poor oral bioavailability due to low water solubility, poor intestinal permeability, and rapid metabolism. Black pepper extract contains piperine, which inhibits enzymes (UGT and CYP3A4) responsible for breaking down and eliminating Curcumin. In human studies, co-administering piperine with Curcumin increased blood concentrations of Curcumin by 2,000% within 45 minutes. Black pepper extract may also provide its own antioxidant and anti-inflammatory properties.

What does the research say about Turmeric Curcumin for joint health?

Multiple systematic reviews and meta-analyses of randomized controlled trials support Curcumin's benefits for joint comfort and function. A 2022 meta-analysis of 29 RCTs across five types of arthritis confirmed its efficacy, and some studies found effects comparable to NSAIDs. A 2025 network meta-analysis found all Turmeric preparations significantly reduced pain scores in knee osteoarthritis. However, the overall evidence quality is rated low to very low due to study limitations.

Is this product non-GMO?

Yes, this Turmeric Curcumin formula is non-GMO. It comes in VegCaps, making it a plant-based capsule option.

Should I be aware of any safety considerations with Turmeric Curcumin?

Curcumin is generally well-tolerated and is recognized by the FDA as GRAS (generally recognized as safe). Gastrointestinal side effects such as nausea or stomach upset have been reported at higher doses but are uncommon and typically mild. Because this formula contains Black pepper extract (piperine), which can inhibit CYP3A4 and P-glycoprotein, it may alter the metabolism of certain medications. Anyone taking prescription drugs should consult a healthcare practitioner. Our naturopath is available for a free consultation if you'd like personalized guidance.

How long has Turmeric been used traditionally?

Turmeric has been utilized for nearly 6,000 years and holds a prominent place in Ayurvedic medicine, traditional Chinese medicine, and Siddha medicine. Historically, it has been used for digestive disorders, inflammatory conditions, skin diseases, and wound healing. It spread from India to China by around 700 AD, to East Africa by 800 AD, and to Europe via Arab merchants in the thirteenth century.

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