Nature’s Way Magnesium Glycinate Complex Guide

Magnesium is the fourth most abundant cation in the human body and a critical cofactor in over 300 enzymatic reactions that regulate energy metabolism, neuromuscular function, cardiovascular health, bone integrity, and psychological well-being. Despite its essential roles, an estimated 56 to 68% of Americans do not obtain enough Magnesium from their daily diet to meet the Recommended Dietary Allowance.

This nature's way Magnesium glycinate complex delivers 184 mg of Magnesium per serving through two highly soluble organic forms — Magnesium citrate and Magnesium malate — chosen for optimum effectiveness. Organic Magnesium forms like citrate and malate are generally more soluble and have higher bioavailability than inorganic forms such as Magnesium oxide, meaning your body can absorb and use them more efficiently.

Formulated to support the cardiovascular system, brain, heart, and kidneys, this Magnesium Complex provides a convenient way to help bridge the gap between what you eat and what your body needs. If you have questions about whether a Magnesium supplement fits your wellness goals, our naturopath is available for a free consultation — no appointment pressure, just honest guidance.

Not all Magnesium supplements are created equal. The form in which Magnesium is delivered affects how well the body absorbs and uses it. This Magnesium Complex pairs two organic forms — citrate and malate — to take advantage of their complementary absorption profiles.

High Solubility, Better Absorption

Research shows that Magnesium citrate has high solubility even in water (55%) and is substantially more soluble than Magnesium oxide across all states of acid secretion. Magnesium malate, another organic salt, shares this solubility advantage. Because both forms are chelated to organic molecules (citric acid and malic acid, respectively), they are generally absorbed more readily than inorganic Magnesium salts.

Broad Enzymatic Support

Once absorbed, the Mg²⁺ ion serves as a cofactor in enzymatic reactions governing protein synthesis, muscle and nerve function, blood glucose control, blood pressure regulation, energy production, oxidative phosphorylation, and glycolysis. It also plays a pivotal role in ATP synthesis — the fundamental energy currency of every cell — making Magnesium indispensable for cellular energy generation across virtually all tissues.

Because Magnesium participates in so many fundamental processes, a wide range of people may benefit from thoughtful supplementation — especially those whose diets fall short of the RDA of 400–420 mg/day for adult men and 310–320 mg/day for adult women.

Older Adults

As we age, Magnesium absorption and retention can decrease. Older people are more susceptible to Magnesium deficiency due to decreased absorption from food, increased medication use (certain diuretics can deplete Magnesium), and potential dietary restrictions. Men older than 70 and teenage girls are among the groups most likely to have low Magnesium intakes.

People Focused on Heart and Cardiovascular Health

Research suggests that higher dietary and circulating Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and total cardiovascular disease. This Magnesium Complex is formulated to support the cardiovascular system, and its highly soluble forms may help individuals looking to maintain healthy heart function.

Those Concerned About Bone Density

Magnesium influences osteoblast and osteoclast activity and affects concentrations of both parathyroid hormone and the active form of vitamin D — two major regulators of bone homeostasis. People with higher Magnesium levels may have higher bone mineral density, which is important in helping reduce the risk of bone fractures.

Individuals on Certain Medications

Several common drug classes — including loop and thiazide diuretics and proton pump inhibitors (PPIs) — can deplete Magnesium over time. If you take any of these medications and are considering a Magnesium supplement, we encourage you to speak with your healthcare provider or take advantage of a free consultation with our naturopath to discuss whether this formula is right for you.

Take 2 capsules twice daily with a meal. Each bottle contains 100 capsules.

Taking Magnesium with food supports absorption and may help minimize the occasional stomach-related side effects — such as softening of stool or mild cramping — that can occur with Magnesium supplements. These side effects are more common with inorganic forms of Magnesium like Magnesium oxide; the organic citrate and malate forms in this complex are generally better tolerated.

Important Interaction Notes

If you take bisphosphonates (such as alendronate), separate your Magnesium dose by at least 2 hours. If you take tetracycline or quinolone antibiotics, take the antibiotic at least 2 hours before or 4–6 hours after Magnesium. Magnesium may also reduce the absorption of gabapentin by approximately 20%. Always consult your healthcare provider if you are on medications that may interact with Magnesium.