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Nature’s Way Magnesium Complex | Heart, Brain & Bone

Discover Nature's Way Magnesium Complex with citrate and malate forms. Learn how this highly soluble formula supports heart health, nervous system, and bone density.

Essential Mineral

Nature's Way Magnesium Complex: Dual-Form Support for Heart, Brain, and Bones

Magnesium is the fourth most abundant mineral in the human body, yet an estimated 56 to 68% of Americans do not get enough of it each day to meet the recommended dietary allowance. That gap matters because Magnesium serves as a cofactor in more than 300 enzyme systems — regulating everything from energy production and blood pressure to nerve signaling and bone formation.

Nature's Way Magnesium Complex addresses this widespread shortfall by combining two organic forms of Magnesium — Magnesium citrate and Magnesium malate — in a single, highly soluble capsule. Two capsules deliver 184 mg of elemental Magnesium in forms chosen specifically for their superior bioavailability compared to common inorganic alternatives like Magnesium oxide. The formula is designed to support the cardiovascular system, brain and kidney function, and bone density.

If you have questions about whether a Magnesium supplement fits your wellness goals, our naturopath is available for a free consultation — no appointment pressure, just honest guidance.

Why These Forms

Citrate and Malate: Why the Form of Magnesium Matters

Not all Magnesium supplements are created equal. Magnesium supplements are broadly categorized into organic and inorganic compounds, and research shows meaningful differences in how well the body absorbs them. Organic forms — such as citrate and malate — involve Magnesium chelated to organic acids, which generally results in higher solubility and bioavailability.

Magnesium citrate, for example, has been shown to have high solubility even in water (55%) and was substantially more soluble than Magnesium oxide in all states of acid secretion. Magnesium oxide, by contrast, was found to be virtually insoluble in water and only 43% soluble even under peak acid conditions. Because Nature's Way Magnesium Complex pairs citrate with malate — both organic forms — the formula is designed to be highly soluble and efficiently absorbed.

This matters for daily supplementation. Better solubility means more of the Magnesium you take actually reaches the tissues that need it: your heart, your nerves, your bones, and your kidneys.

What's inside

Key Ingredients

Magnesium citrate — 184 mg
Magnesium citrate is one of the most bioavailable supplemental forms of Magnesium, with high solubility in water (55%) that leads to efficient absorption — substantially more soluble than inorganic forms like Magnesium oxide. Research supports Magnesium's wide-ranging roles across multiple body systems. For cardiovascular health, large meta-analyses and prospective cohort studies consistently associate higher Magnesium levels with lower risks of coronary heart disease, stroke, and total cardiovascular disease; supplementation has been shown in multiple RCTs and meta-analyses to modestly but significantly reduce blood pressure, particularly in Magnesium-deficient or hypertensive individuals, through mechanisms including vasodilation, calcium channel antagonism, and RAAS modulation. Magnesium is also a well-established cofactor in cardiac electrophysiology, modulating ion channel exchanges and action potentials; hypomagnesemia is strongly linked to ventricular and supraventricular arrhythmias. A 24-week RCT with 350 mg/day Magnesium citrate significantly reduced arterial stiffness as measured by pulse wave velocity. For bone density, Magnesium is an essential cofactor in bone mineral metabolism, enzyme activity for bone matrix synthesis, and vitamin D activation; observational data from large cohort studies found higher Magnesium intake associated with 2–3% greater bone density in women, and clinical trials show supplementation may attenuate bone loss. As the second most abundant mineral in bone, low Magnesium is associated with increased osteoporosis risk through promoted osteoclast activity and disrupted calcium homeostasis. For the nervous system, Magnesium acts as a natural NMDA receptor antagonist, modulating synaptic transmission and neuronal excitability; deficiency is clinically associated with neuromuscular hyperexcitability, tremors, and neurological disorders. Magnesium also plays a critical role in nerve excitability by regulating calcium and potassium channels, and clinical evidence supports its role in nerve excitability modulation and neuropathic pain reduction. As a cofactor in dopamine synthesis and a blocker of NMDA glutamate receptor channels, Magnesium supports inhibitory-excitatory neurotransmitter balance. Additionally, Magnesium has documented roles in the musculoskeletal system — governing calcium flux in muscle and bone cells, reducing muscle soreness, and supporting muscle mass preservation in aging populations. A 2022 meta-analysis of 17 RCTs found Magnesium supplementation significantly decreased serum C-reactive protein (CRP) and increased nitric oxide (NO) levels, supporting its role in a healthy inflammatory response.
Magnesium malate — 184 mg
Magnesium malate is an organic form of Magnesium chelated to malic acid, offering generally higher solubility and bioavailability compared to inorganic alternatives. Like the citrate form, Magnesium malate delivers the same essential Mg²⁺ ion that serves as a cofactor across hundreds of enzymatic reactions. Research supports its contributions to cardiovascular health — higher dietary and circulating Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and cardiovascular disease in multiple large meta-analyses, and Magnesium regulates cardiac excitation, vascular tone, and endothelial function. For bone health, Magnesium influences osteoblast and osteoclast activity and affects concentrations of both parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis; a systematic review and meta-analysis found that higher Magnesium intake is associated with increased hip and femoral neck bone mineral density in older adults. Magnesium malate also supports the nervous system by acting as a physiological NMDA receptor antagonist and regulator of neuronal excitability and neuromuscular transmission. Hypomagnesemia is clinically associated with neuromuscular hyperexcitability, tremors, and seizures. The mineral is indispensable for cellular energy generation through its pivotal role in ATP synthesis, and it participates in insulin secretion and insulin receptor signaling. Magnesium malate pairs these systemic benefits with its organic-acid chelation, contributing to the highly soluble profile of the Nature's Way Magnesium Complex formula.
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Who Benefits

Who May Benefit from Nature's Way Magnesium Complex

Because Magnesium plays such a far-reaching role in the body, a wide range of people may find this formula helpful. Adults who want to support their cardiovascular system may appreciate that research consistently associates adequate Magnesium with heart-healthy markers such as normal blood pressure and healthy arterial function.

Those focused on bone density — including postmenopausal women — may benefit as well. Studies suggest that Magnesium is involved in bone formation, influences osteoblast and osteoclast activity, and is required for vitamin D activation, all of which are central to skeletal health.

Older adults deserve special attention. As we age, Magnesium absorption and retention can decrease, and factors like increased medication use (certain diuretics and proton pump inhibitors can deplete Magnesium) may compound the shortfall. Men over 70 and teenage girls are identified as groups most likely to have low intakes.

Individuals with gastrointestinal disorders, those with type 2 diabetes, and people on long-term medications that affect Magnesium status are also more likely to have inadequate levels. If you're unsure whether supplemental Magnesium is right for your situation, our naturopath can help you think it through during a free consultation.

How to Take

Directions for Use

Take 2 capsules twice daily with a meal.

Each bottle contains 100 capsules. Because Magnesium can interact with certain medications — including bisphosphonates, tetracycline and quinolone antibiotics, diuretics, proton pump inhibitors, and gabapentin — it is important to separate dosing from these medications. Bisphosphonates should be taken at least 2 hours apart from Magnesium, and antibiotics should be taken at least 2 hours before or 4–6 hours after Magnesium supplementation.

As with any supplement, consult your healthcare provider before starting if you are pregnant, nursing, taking prescription medications, or managing a health condition.

About the author

Written by Greg Howlett

GH

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What forms of Magnesium are in Nature's Way Magnesium Complex?

Nature's Way Magnesium Complex contains two organic forms: Magnesium citrate and Magnesium malate. Both are organic salts that are generally more soluble and have higher bioavailability than inorganic forms like Magnesium oxide. Magnesium citrate, for instance, has been shown to have high solubility even in water (55%), compared to Magnesium oxide which was virtually insoluble in water.

How much Magnesium does each serving provide?

Two capsules (one serving) provide 184 mg of elemental Magnesium. The label directions recommend taking 2 capsules twice daily with a meal.

What body systems does this Magnesium formula support?

The formula is designed to support the cardiovascular system, brain and kidney function, nervous system health, and bone density. Magnesium is a cofactor in more than 300 enzyme systems and plays documented roles in heart rhythm, blood pressure regulation, bone formation, neuronal excitability, and energy production.

Can Magnesium supplements interact with medications?

Yes. Magnesium can interact with several classes of medications. It may decrease absorption of oral bisphosphonates (separate by at least 2 hours), form insoluble complexes with tetracycline and quinolone antibiotics (take the antibiotic at least 2 hours before or 4–6 hours after Magnesium), and reduce absorption of gabapentin by approximately 20%. Additionally, loop and thiazide diuretics and long-term use of proton pump inhibitors can deplete Magnesium. Talk with your healthcare provider if you take any of these medications.

Why is Magnesium deficiency so common?

Research estimates that between 56 and 68% of Americans do not obtain enough Magnesium daily to meet the recommended dietary allowance. Contributing factors include inadequate dietary intake, chronic diseases, aging (which reduces Magnesium absorption and retention), and the use of medications that deplete Magnesium. Men over 70 and teenage girls are among the groups most likely to have low intakes.

Are there side effects from taking Magnesium supplements?

The most common side effects are stomach-related — including softening of stool, nausea, cramps, and diarrhea — and these tend to occur at higher doses and more often with inorganic forms like Magnesium oxide. Organic forms such as citrate and malate are generally better tolerated. Hypermagnesemia from supplemental intake is rare in individuals with normal kidney function because the kidneys efficiently excrete excess Magnesium.

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