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Nature Made Magnesium Complex with D3 and Zinc

Discover how Nature's Sunshine Magnesium Complex with citrate & malate supports heart health, the nervous system, and muscles. 184 mg per 2-capsule serving.

Overview

Nature Made Magnesium Complex with D3 and Zinc: What It Is and Why It Matters

If you're searching for a nature made Magnesium Complex with d3 and zinc, you've likely recognized just how critical Magnesium is for everyday well-being. Nature's Sunshine Magnesium Complex is a focused Magnesium supplement that delivers 184 mg of Magnesium per two-capsule serving in two highly soluble organic forms — Magnesium citrate and Magnesium malate — chosen specifically for optimum effectiveness and absorption.

Magnesium is the fourth most abundant cation in the human body and serves as a cofactor in more than 300 enzyme systems that regulate everything from energy production and muscle contraction to nerve signaling and cardiovascular rhythm. Despite its importance, it is estimated that between 56 and 68% of Americans do not obtain enough Magnesium in their daily diet to meet the Recommended Dietary Allowance. That widespread gap is one reason so many people turn to a quality Magnesium Complex.

This formula is designed to support the cardiovascular system, help brain, kidney, and heart functions, and provide the Magnesium your muscles and nerves need to function properly. The 100-capsule bottle makes it easy to maintain a consistent daily routine.

Bioavailable Forms

Why Citrate and Malate: Two Highly Soluble Forms of Magnesium

Not all Magnesium supplements are created equal. Magnesium supplements are broadly categorized into organic and inorganic compounds. Organic forms — such as citrate, malate, glycinate, and lactate — involve Magnesium chelated to organic molecules, and they are generally more soluble and have higher bioavailability than inorganic forms like Magnesium oxide.

Magnesium Complex combines Magnesium citrate and Magnesium malate, both organic forms. Research shows that Magnesium citrate has high solubility even in water (55%) and is substantially more soluble than Magnesium oxide in all states of acid secretion. This matters because higher solubility translates to more efficient absorption in your digestive tract.

By pairing two complementary organic forms, this formula is described as highly soluble — an important quality for anyone who wants to make the most of each capsule. If you have questions about which form of Magnesium is right for your individual needs, our naturopath is available for a free consultation.

What's inside

Key Ingredients

Magnesium citrate — 184 mg
Magnesium citrate is one of the most bioavailable supplemental forms of Magnesium, with high water solubility (55%) and substantially greater solubility than Magnesium oxide across all states of acid secretion. As a cofactor in over 300 enzymatic reactions, Magnesium supports energy production via ATP synthesis, muscle and nerve function, blood glucose regulation, and blood pressure management. Research suggests Magnesium plays a well-documented role in cardiovascular health: higher dietary and circulating Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and total cardiovascular disease across multiple large meta-analyses. Magnesium is also a well-established cofactor in cardiac electrophysiology, modulating ion channel exchanges and action potentials; hypomagnesemia is strongly linked to ventricular and supraventricular arrhythmias. For the nervous system, Magnesium acts as a natural NMDA receptor antagonist, modulating synaptic transmission and neuronal excitability — deficiency is associated with neuromuscular hyperexcitability, tremors, and neurological conditions ranging from migraine to depression. Regarding muscle health, Magnesium is the most studied mineral supplement for skeletal muscle cramps; deficiency impairs muscle relaxation, as muscles contract normally but struggle to fully release when Magnesium levels are low. A 2024 systematic review found that Magnesium supplementation reduced muscle soreness, improved performance and recovery, and exerted a protective effect on muscle damage in physically active individuals. Supplementation has also been shown in a 24-week RCT to significantly reduce arterial stiffness as measured by pulse wave velocity. Additionally, Magnesium plays a critical role in nerve excitability by blocking NMDA receptors and regulating calcium and potassium channels, with clinical evidence supporting its use for nerve excitability modulation and neuropathic pain reduction. A 2017 RCT showed 248 mg/day Magnesium significantly reduced both depression and anxiety scores, supporting its role in neurotransmitter balance. Low serum Magnesium levels have also been associated with greater restless leg syndrome severity, and a randomized controlled trial found Magnesium supplementation significantly improved both RLS symptom scores and sleep quality.
Magnesium malate — 184 mg
Magnesium malate is an organic form of Magnesium chelated to malic acid. Like Magnesium citrate, organic Magnesium forms are generally more soluble and have higher bioavailability compared to inorganic alternatives such as Magnesium oxide. Magnesium malate contributes the same essential Mg²⁺ ion that serves as a cofactor for more than 300 enzymatic reactions in the body, including those governing ATP synthesis, oxidative phosphorylation, and glycolysis — making it indispensable for cellular energy generation. For heart health, research suggests that Magnesium regulates cardiac ion channels, myocardial conduction, and contraction, and large meta-analyses and prospective cohort studies consistently associate higher Magnesium levels with lower risks of coronary heart disease, atrial fibrillation, and heart failure. Multiple RCTs and meta-analyses show Magnesium supplementation modestly but significantly reduces blood pressure, particularly in Magnesium-deficient or hypertensive individuals, through mechanisms including vasodilation and calcium channel antagonism. Magnesium is fundamental to nervous system function, acting as a physiological NMDA receptor antagonist and regulator of neuronal excitability and neuromuscular transmission. Hypomagnesemia is clinically associated with neuromuscular hyperexcitability, tremors, and seizures. For muscles, Magnesium is an essential cofactor for ATP synthesis and utilization, muscle contraction, and electrolyte homeostasis; deficiency is associated with muscle cramps, weakness, and impaired exercise performance, and supplementation in deficient individuals may restore muscle function. Magnesium also suppresses pro-inflammatory cytokines (IL-6, TNF-α) relevant to exercise recovery, and a 2022 meta-analysis of 17 RCTs found that Magnesium supplementation significantly decreased serum C-reactive protein and increased nitric oxide levels. Additionally, Magnesium is involved in bone formation, influencing osteoblast and osteoclast activity as well as concentrations of vitamin D and parathyroid hormone, both major regulators of bone homeostasis.
Magnesium Complex
Magnesium Complex
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Magnesium Complex
Magnesium Complex
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Who Benefits

Who Is Magnesium Complex For?

This formula is a good fit for a wide range of adults, but certain groups may find it especially relevant. Older adults are more susceptible to Magnesium deficiency due to decreased absorption from food, increased medication use (diuretics can deplete Magnesium), and potential dietary restrictions. Men older than 70 and teenage girls are among those most likely to have low intakes.

People who take proton pump inhibitors (PPIs), loop or thiazide diuretics, or certain antibiotics long-term should be aware that these medications can affect Magnesium status. Individuals with type 2 diabetes, gastrointestinal disorders, or alcohol dependence are also at elevated risk for Magnesium inadequacy.

Active individuals may appreciate that exercise can increase Magnesium requirements by 10–20%, and research suggests Magnesium supplementation may help reduce muscle soreness and support recovery. Anyone looking for cardiovascular, nervous system, or musculoskeletal support — or who simply suspects their diet falls short of the 310–420 mg daily RDA — may want to consider a well-absorbed Magnesium Complex like this one.

If you're not sure whether supplemental Magnesium is right for you, or you have questions about how it may interact with your current medications, our naturopath offers free consultations and is happy to help you sort things out.

Directions

How to Take Magnesium Complex

Take 2 capsules twice daily with a meal.

Each two-capsule serving provides 184 mg of Magnesium. The Recommended Dietary Allowance for Magnesium is 400–420 mg/day for adult men and 310–320 mg/day for adult women, so two servings daily — along with the Magnesium you get from foods like leafy greens, nuts, seeds, and whole grains — can help you work toward meeting your daily needs.

Important timing notes: If you take bisphosphonates (such as alendronate), separate them from Magnesium by at least 2 hours. If you take tetracycline or quinolone antibiotics, take the antibiotic at least 2 hours before or 4–6 hours after Magnesium to avoid absorption interference. Magnesium may also reduce the absorption of gabapentin by approximately 20%.

Safety

Safety Considerations and Drug Interactions

Magnesium supplements are generally well tolerated. The most common side effects are stomach-related — nausea, cramping, or softened stool — and these tend to occur at higher doses and are more common with inorganic forms like Magnesium oxide. Because this formula uses organic citrate and malate forms, gastrointestinal comfort may be improved.

The Tolerable Upper Intake Level (UL) set by the Food and Nutrition Board is 350 mg of Magnesium from supplements only (this does not include Magnesium from food). Hypermagnesemia from supplemental intake is rare in individuals with normal kidney function, as the kidneys efficiently excrete excess Magnesium. Risk is substantially elevated in individuals with impaired renal function.

Several medications can interact with Magnesium status. Loop and thiazide diuretics deplete Magnesium through increased urinary excretion, while potassium-sparing diuretics reduce Magnesium loss. Prescription proton pump inhibitors taken for prolonged periods (typically more than a year) can cause hypomagnesemia. Always discuss new supplements with your healthcare provider, especially if you take prescription medications.

About the author

Written by Greg Howlett

GH

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What forms of Magnesium are in this Magnesium Complex?

This formula contains two organic forms: Magnesium citrate and Magnesium malate. Both are highly soluble. Research shows Magnesium citrate has 55% solubility in water and is substantially more soluble than inorganic forms like Magnesium oxide. Organic Magnesium forms are generally better absorbed by the body.

How much Magnesium does each serving provide?

Two capsules (one serving) provide 184 mg of Magnesium. The suggested use is two servings per day (2 capsules twice daily with a meal), for a total of 368 mg of supplemental Magnesium daily. The RDA for Magnesium is 400–420 mg/day for adult men and 310–320 mg/day for adult women, and this amount includes Magnesium from all sources including food.

Does this product contain vitamin D3 or zinc?

This Nature's Sunshine Magnesium Complex focuses specifically on Magnesium in citrate and malate forms. The ingredient label lists Magnesium citrate and Magnesium malate. If you are looking for a formula that also includes vitamin D3 or zinc, our naturopath can help you find a complementary product during a free consultation.

Can Magnesium supplements interact with medications?

Yes. Magnesium can decrease the absorption of bisphosphonates, tetracycline antibiotics, and quinolone antibiotics — these medications should be separated from Magnesium by at least 2 hours (4–6 hours for tetracyclines and quinolones). Loop and thiazide diuretics can deplete Magnesium, while long-term use of proton pump inhibitors may cause low Magnesium levels. Magnesium may also reduce the absorption of gabapentin by about 20%. Always consult your healthcare provider before combining supplements with prescription medications.

Who is most at risk for Magnesium deficiency?

It is estimated that 56–68% of Americans don't meet the RDA for Magnesium. Those at highest risk include older adults (due to decreased absorption and increased medication use), individuals with type 2 diabetes, people with gastrointestinal disorders, those with alcohol dependence, men over 70, and teenage girls. Early symptoms of deficiency include fatigue, weakness, loss of appetite, and muscle cramps.

Does research support Magnesium for heart health and muscle cramps?

Research suggests that higher Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and total cardiovascular disease across multiple large meta-analyses. For muscle cramps, Magnesium is the most studied mineral supplement; deficiency impairs muscle relaxation, as muscles contract normally but struggle to fully release when levels are low. While the evidence is strongest for people who are Magnesium-deficient, maintaining adequate Magnesium intake supports both cardiovascular and musculoskeletal function.

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